Compounds
#tirzepatide
Tirzepatide. Dual GIP/GLP-1, 2.5 to 15mg, SURMOUNT and SURPASS.
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Dual GIP/GLP-1 receptor agonism: what the GIP arm appears to add, why many people find it easier on the gut than a pure GLP-1, the 2.5 → 15mg ladder, the long-running argument about whether anyone needs to go past 7.5mg, and the absence of any clean sema-to-tirz dose equivalence.
Pinned in this channel
There is no clean conversion between semaglutide and tirzepatide doses. Anyone who gives you one has made it up. Restart the ladder low.
SURMOUNT-1 (NEJM 2022) for weight, SURPASS-2 (NEJM 2021) for the head-to-head against semaglutide 1mg, SURMOUNT-OSA (NEJM 2024) for sleep apnoea.
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Most recent logs
2026-06-30ok so is 7.5 really the sweet spot or is that just channel folklore46 msgs · 8 people2026-06-28went back to semaglutide after 24 months because the cost difference mattered more than the GI45 msgs · 9 people2026-06-27does the GIP arm actually explain the easier nausea or is that hand waving29 msgs · 8 people2026-06-25plateaued at 18 weeks the same way i did on semaglutide, so i doubt its compound specific went back to semaglutide…75 msgs · 15 people2026-06-24titrate slow47 msgs · 12 people2026-06-22plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific47 msgs · 10 people2026-06-21did going from 2 semaglutide to 5 of this feel like a step down for anyone24 msgs · 5 people2026-06-20i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more56 msgs · 11 people2026-06-19did anybody switch back to semaglutide after trying this49 msgs · 11 people2026-06-18at 2.4 my appetite is gone entirely, did anyone go down rather than up51 msgs · 12 people2026-06-1710 was enough67 msgs · 12 people2026-06-16went back to semaglutide after 22 months because the cost difference mattered more than the GI53 msgs · 14 people2026-06-15GI was noticeably easier for me than semaglutide at what felt like the same appetite effect72 msgs · 12 people2026-06-14no gap when i switched, took the last semaglutide dose and started this a week later79 msgs · 14 people2026-06-13€240 for a 15 vial is roughly what ive paid for the last year25 msgs · 6 people2026-06-12switched last year43 msgs · 9 people2026-06-11the two compounds arent interchangeable week for week even if the effect ends up similar went back to semaglutide…16 msgs · 4 people2026-06-10i sat at 7.5 for 14 months and never needed more, which is where the folklore comes from42 msgs · 8 people2026-06-09im at 1 and thinking about 0.5, did anyone gain anything from that step16 msgs · 4 people2026-06-085 did nothing35 msgs · 8 people2026-06-07i went to 15 and came back to 10, more suppression wasnt more useful for me29 msgs · 6 people2026-06-06Verification log updated: JEEP — evidence added, status unchanged.33 msgs · 9 people2026-06-05im at 15 and thinking about 10, did anyone gain anything from that step52 msgs · 11 people2026-06-04does switching from semaglutide need a gap or do you just start24 msgs · 5 people2026-06-03anyone stopped at 10 and stayed there for months20 msgs · 5 people2026-06-02is SURMOUNT-OSA the sleep apnoea one56 msgs · 12 people2026-06-01dual agonist, GIP as well as GLP-1, thats the whole difference in one line42 msgs · 9 people2026-05-31i went to 15 and came back to 10, more suppression wasnt more useful for me24 msgs · 6 people2026-05-30SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted26 msgs · 4 people2026-05-29checked the units twice53 msgs · 12 people
Threads spun off from this channel
at 2.4 my appetite went completely and i dropped2026-06-30 · 17 msgssorry to jump in no gap when i switched2026-06-28 · 7 msgsright so at 15 the GI came back for2026-06-27 · 14 msgsthe GI difference held for me right up to2026-06-19 · 8 msgsi went to 15 and came back to 102026-06-15 · 8 msgsis SURMOUNT-OSA the sleep apnoea one2026-06-05 · 14 msgsthe sweet spot thing is survivorship, the people it2026-05-13 · 5 msgs40 units of a 2 solution is a lot2026-05-07 · 5 msgsanyone got a 2.5 recon they like for the2026-04-22 · 12 msgsdid anyone go past 15 and was there any2026-04-16 · 13 msgschanged my mind about needing 15, i was chasing2026-04-05 · 12 msgslicensed top is 15 weekly, past that is not2026-04-01 · 15 msgsslightly off topic but whats the plateau pattern here2026-03-28 · 17 msgsdoes the appetite effect feel different or just stronger2026-03-21 · 11 msgsslightly off topic but whats the top licensed dose2026-03-15 · 6 msgsdoes switching from semaglutide need a gap or do2026-03-07 · 10 msgscoming off semaglutide, is there a conversion or do2026-03-05 · 6 msgsis SURMOUNT-OSA the sleep apnoea one2026-03-01 · 15 msgsdoes the appetite effect feel different or just stronger2026-01-17 · 16 msgs12 did nothing extra over 10 for me and2025-12-12 · 17 msgsis the 40 vial the common one or do2025-11-09 · 13 msgsupdate on the earlier thing same plateau here2025-11-02 · 12 msgsdid anybody switch back to semaglutide after trying this2025-10-19 · 8 msgsthere is no clean conversion between the two, anyone2025-10-03 · 6 msgs