5 was where i first noticed it properly, 2.5 did almost nothing for me, not advice obviously
#tirzepatide 2026-02-21
Saturday36 messages10 participantstimes are UTC
Highlights from this day
- VialBot — Reminder set. I will post here in 5 days. 19:11
- willow_waits — does the GIP arm actually explain the easier nausea or is that hand waving the GI difference held for me right up to 15, which isnt what a couple of people here found 19:45
- amylin_amy — at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win 19:59
- alt_ast_ali — for the archive my Medutest result on a FGP vial came in at 98.1 which is why i keep buying from them 20:58
- half_life_hal — if youre coming off semaglutide the honest answer is start low and find out, theres no table 20:59
12 did nothing extra over 10 for me and that still holds a year later, thats just me
im at 12 and thinking about 2, did anyone gain anything from that step
same plateau here
there is no clean conversion between the two, anyone giving you a ratio is guessing
5 did nothing
easier gi for me
Reminder set. I will post here in 5 days.
the two compounds arent interchangeable week for week even if the effect ends up similar
the sweet spot argument is really about effect per side effect, not a magic number
no clean conversion
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genuine question no gap when i switched, took the last semaglutide dose and started this a week later
sorry to jump in SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, not advice obviously
genuine question i went to 15 and came back to 10, more suppression wasnt more useful for me
genuine question at 12 my appetite is gone entirely, did anyone go down rather than up
does the GIP arm actually explain the easier nausea or is that hand waving
the GI difference held for me right up to 15, which isnt what a couple of people here found
the trials titrated every four weeks to a target, most people here stop at whatever works
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
❤️9
at 15 the GI came back for me, so my easier profile claim only applies below that
plateaued at 17 weeks the same way i did on semaglutide, so i doubt its compound specific
changed my mind about needing 15, i was chasing a number rather than an outcome
my Medutest result on a KP vial came in at 99 which is why i keep buying from them
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
SURMOUNT is weight
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the sweet spot thing is survivorship, the people it worked for stayed and said so
*PeptideMeter not the other one
40 units of a 4 solution is a lot of volume and i check that one twice every single time
for the archive my Medutest result on a FGP vial came in at 98.1 which is why i keep buying from them
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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the switch felt like a step down at first and then caught up around week 6
went back to semaglutide after 8 months because the cost difference mattered more than the GI
checked the units twice
switched last year
sorry to jump in the 2.5 to 5 step was the roughest one for me and everything after was easier
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect