at 15 the GI came back for me, so my easier profile claim only applies below that
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
#tirzepatide 2026-04-01
Wednesday32 messages7 participantstimes are UTC
Highlights from this day
- gall_bladder_gav — changed my mind about needing 15, i was chasing a number rather than an outcome 15:11
- void_volume — whats the top licensed dose, 15 or does it go higher 15:14
- tga_notice — is SURMOUNT-OSA the sleep apnoea one 17:40
- belfast_bac — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 19:01
*Medutest not the other one
while im here i log everything and my appetite curve looks flatter across the week than my semaglutide log did
changed my mind about needing 15, i was chasing a number rather than an outcome
coa-a-2418.pdf
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did anyone find the GI easier than semaglutide at an equivalent effect
whats the top licensed dose, 15 or does it go higher
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)✅5📉13
did anybody switch back to semaglutide after trying this
12 did nothing extra over 10 for me and that still holds a year later
switched last year
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
quick one at 10 my appetite is gone entirely, did anyone go down rather than up
7.5 gang
titrate slow
went back to semaglutide after 15 months because the cost difference mattered more than the GI
[edited]£72 for a 15 vial is roughly what ive paid for the last year
anyone tracked whether the GI difference held at the top doses
folklore probably
i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more
no clean conversion
does the GIP arm actually explain the easier nausea or is that hand waving
is SURMOUNT-OSA the sleep apnoea one
💀1📉16👀1
5 did nothing
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i went to 15 and came back to 10, more suppression wasnt more useful for me
does switching from semaglutide need a gap or do you just start
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GIP plus GLP-1
the sweet spot thing is survivorship, the people it worked for stayed and said so
the sweet spot argument is really about effect per side effect, not a magic number
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, i think
anyone stopped at 10 and stayed there for months
easier gi for me
slightly off topic but the trials titrated every four weeks to a target, most people here stop at whatever works