is SURMOUNT-OSA the sleep apnoea one
#tirzepatide 2026-05-15
Friday41 messages8 participantstimes are UTC
Highlights from this day
- tokyo_taper — switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it 22:34
- net_peptide — i sat at 7.5 for 17 months and never needed more, which is where the folklore comes from 23:05
- tokyo_taper — how long before the dual thing was noticeable to you 23:08
- endotoxin_ed — 40 units of a 2 solution is a lot of volume and i check that one twice every single time 23:41
22:30ferrous_ash pinned a message to this channel
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, we shall see
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
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22:36ferrous_ash pinned a message to this channel
checked the units twice
how did people handle the 2.5 to 5 jump
held 10 for 23 months and lost 15kg over that stretch, slow and boring and fine
Channel stats, last 30 days: 108 messages from 21 members.
whats the top licensed dose, 15 or does it go higher
switched last year
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
£185 for a 2 vial is roughly what ive paid for the last year, n of 1 obviously
anyone stopped at 10 and stayed there for months
im at 1.7 and thinking about 12, did anyone gain anything from that step
[edited]no gap when i switched, took the last semaglutide dose and started this a week later
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
easier gi for me
12 did nothing extra over 10 for me and that still holds a year later
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i went to 15 and came back to 10, more suppression wasnt more useful for me
23:02ferrous_ash pinned a message
did going from 10 semaglutide to 5 of this feel like a step down for anyone
i sat at 7.5 for 17 months and never needed more, which is where the folklore comes from
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)5 did nothing
how long before the dual thing was noticeable to you
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went back to semaglutide after 12 months because the cost difference mattered more than the GI
at 15 the GI came back for me, so my easier profile claim only applies below that, for what its worth
5 was where i first noticed it properly, 2.5 did almost nothing for me
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
titrate slow
the trials titrated every four weeks to a target, most people here stop at whatever works
restarted at 2.5 after 25 months off and the first two doses reminded me why titration exists
why does everyone talk about 7.5 and not 10
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
folklore probably
ok so back after 26 months, do i restart at 2.5 or pick up near where i left off
is 7.5 really the sweet spot or is that just channel folklore
40 units of a 2 solution is a lot of volume and i check that one twice every single time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT is weight
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
[edited]the two compounds arent interchangeable week for week even if the effect ends up similar