is SURMOUNT-OSA the sleep apnoea one
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#tirzepatide 2026-06-02
Tuesday56 messages12 participantstimes are UTC
Highlights from this day
- residual_solvent — the 20 vial in 2ml gives 5mg/ml which puts 5 on 8 units, nice round numbers 22:42
- noct.titrate — plateaued at 20 weeks the same way i did on semaglutide, so i doubt its compound specific 23:14
- jute_journals — quick one anyone stopped at 10 and stayed there for months held 10 for 24 months and lost 18kg over that stretch, slow and boring and fine 23:58
Reminder set. I will post here in 4 days.
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did anyone find the GI easier than semaglutide at an equivalent effect
genuine question the sweet spot thing is survivorship, the people it worked for stayed and said so
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40 units of a 8 solution is a lot of volume and i check that one twice every single time
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*that should say weekly
how many weeks at 7.5 before you knew it was enough
easier gi for me
is there a reason to titrate slower than the four week schedule
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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genuine question does the GIP arm actually explain the easier nausea or is that hand waving
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
for the archive i log everything and my appetite curve looks flatter across the week than my semaglutide log did, anyway
titrate slow
follow up i argued the sweet spot was nonsense and then spent 23 months at 7.5 not needing more
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restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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at 0.25 my appetite is gone entirely, did anyone go down rather than up
my VendorInvestigate result on a MKM vial came in at 98.6 which is why i keep buying from them, i think
21:52tenpence pinned a message
the sweet spot argument is really about effect per side effect, not a magic number
back after 3 months, do i restart at 2.5 or pick up near where i left off
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
while im here does switching from semaglutide need a gap or do you just start
the switch felt like a step down at first and then caught up around week 8
quick one GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
anyone tracked whether the GI difference held at the top doses
update on the earlier thing switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it
the 2.5 to 5 step was the roughest one for me and everything after was easier
start low anyway
SURMOUNT is weight
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GIP plus GLP-1
the trials titrated every four weeks to a target, most people here stop at whatever works
10 was enough
i went to 15 and came back to 10, more suppression wasnt more useful for me
there is no clean conversion between the two, anyone giving you a ratio is guessing
did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
at 15 the GI came back for me, so my easier profile claim only applies below that
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15 is the top
unrelated but how did people handle the 2.5 to 5 jump
the 20 vial in 2ml gives 5mg/ml which puts 5 on 8 units, nice round numbers
janoshik-a-2601.pdf
2 pages · 518 KB · not retained in the public archive
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is the sweet spot argument about effect or about side effects
coming off semaglutide, is there a conversion or do i restart at 2.5
is the 5 vial the common one or do people use 40
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$72 for a 15 vial is roughly what ive paid for the last year
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the two compounds arent interchangeable week for week even if the effect ends up similar
janoshik-d-0718.pdf
2 pages · 918 KB · not retained in the public archive
5 was where i first noticed it properly, 2.5 did almost nothing for me
held 10 for 12 months and lost 19kg over that stretch, slow and boring and fine
did anybody switch back to semaglutide after trying this
the GI difference held for me right up to 15, which isnt what a couple of people here found, happy to be corrected
plateaued at 20 weeks the same way i did on semaglutide, so i doubt its compound specific
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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no gap when i switched, took the last semaglutide dose and started this a week later
anyone got a 2.5 recon they like for the 15 vials
went back to semaglutide after 11 months because the cost difference mattered more than the GI
folklore probably
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quick one anyone stopped at 10 and stayed there for months
held 10 for 24 months and lost 18kg over that stretch, slow and boring and fine
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