my VendorInvestigate result on a MKM vial came in at 98.6 which is why i keep buying from them
#tirzepatide 2025-10-25
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Highlights from this day
titrate slow
vial-e-2205-front.png
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does the GIP arm actually explain the easier nausea or is that hand waving
Archive lookup: dose_day_drift first appears in this channel on 2025-07-28.
no clean conversion
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40 units of a 4 solution is a lot of volume and i check that one twice every single time
restarted at 2.5 after 21 months off and the first two doses reminded me why titration exists
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
5 was where i first noticed it properly, 2.5 did almost nothing for me
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ok so anyone tracked whether the GI difference held at the top doses
10 was enough
[edited]the GI difference held for me right up to 15, which isnt what a couple of people here found
is 7.5 really the sweet spot or is that just channel folklore
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12 did nothing extra over 10 for me and that still holds a year later
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7.5 gang
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unrelated but does switching from semaglutide need a gap or do you just start
the sweet spot argument is really about effect per side effect, not a magic number
whats the plateau pattern here, same as semaglutide or different
at 15 the GI came back for me, so my easier profile claim only applies below that
at 1 my appetite went completely and i dropped back a step, eating nothing isnt a win
start low anyway
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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sorry to jump in i argued the sweet spot was nonsense and then spent 9 months at 7.5 not needing more
changed my mind about needing 15, i was chasing a number rather than an outcome
same plateau here
Reminder for LC_MS_Lena: dose day is today. Set 7 days ago.
the sweet spot thing is survivorship, the people it worked for stayed and said so
checked the units twice
is the 2 vial the common one or do people use 15
whats the top licensed dose, 15 or does it go higher
5 did nothing
coming off semaglutide, is there a conversion or do i restart at 2.5
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)how many weeks at 7.5 before you knew it was enough