#tirzepatide 2025-11-16

Sunday24 messages4 participantstimes are UTC

Highlights from this day

sgp_subq — is there a reason to titrate slower than the four week schedule 23:11
gip_glp_gil — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 23:24
gip_glp_gil — $38 for a 15 vial is roughly what ive paid for the last year 23:45

the sweet spot thing is survivorship, the people it worked for stayed and said so

at 2 my appetite is gone entirely, did anyone go down rather than up
if youre coming off semaglutide the honest answer is start low and find out, theres no table

15 is the top

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impersonator_ip 23:05

how many weeks at 7.5 before you knew it was enough

gip_glp_gil 23:07

did anybody switch back to semaglutide after trying this

impersonator_ip 23:09

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

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gip_glp_gil did anybody switch back to semaglutide after trying this

sgp_subq 23:11

is there a reason to titrate slower than the four week schedule

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7.5 gang

impersonator_ip 23:14

titrate slow

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update on the earlier thing im at 7.5 and thinking about 0.25, did anyone gain anything from that step

start low anyway

	Trial schedule	What most people here do
Step interval	4 weeks, fixed	4-12 weeks, on symptoms
Holding	protocol deviation	normal and expected
Top dose	reached by design	often never reached
Coming down	not studied	common at maintenance

the two compounds arent interchangeable week for week even if the effect ends up similar

gip_glp_gil 23:20

is the sweet spot argument about effect or about side effects

restarted at 2.5 after 16 months off and the first two doses reminded me why titration exists

[edited]

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

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secretagogue_sy 23:27

SURMOUNT is weight

[edited]

gip_glp_gil 23:30

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

plateaued at 26 weeks the same way i did on semaglutide, so i doubt its compound specific

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easier gi for me

sgp_subq 15 is the top

secretagogue_sy 23:35

folklore probably

whats the top licensed dose, 15 or does it go higher

gip_glp_gil 23:44

switched last year

$38 for a 15 vial is roughly what ive paid for the last year

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at 15 the GI came back for me, so my easier profile claim only applies below that

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