follow up changed my mind about needing 15, i was chasing a number rather than an outcome
#tirzepatide 2025-08-21
Thursday15 messages5 participantstimes are UTC
Highlights from this day
- mira_pins — follow up changed my mind about needing 15, i was chasing a number rather than an outcome 09:06
- mira_pins — $120 for a 10 vial is roughly what ive paid for the last year 09:16
- hiccup_hollis — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 14:02
- hiccup_hollis — i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more 14:06
- third_shift — went back to semaglutide after 23 months because the cost difference mattered more than the GI 14:07
$120 for a 10 vial is roughly what ive paid for the last year
transit-times.csv
868 rows · not retained in the public archive
12 did nothing extra over 10 for me and that still holds a year later
anyone stopped at 10 and stayed there for months
SURMOUNT is weight
the sweet spot argument is really about effect per side effect, not a magic number
same plateau here
5 was where i first noticed it properly, 2.5 did almost nothing for me
no gap when i switched, took the last semaglutide dose and started this a week later
7.5 gang
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
there is no clean conversion between the two, anyone giving you a ratio is guessing
[edited]i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
🎉1😂15
went back to semaglutide after 23 months because the cost difference mattered more than the GI
📉1💀4😂1
unrelated but does the GIP arm actually explain the easier nausea or is that hand waving