Compounds
#oral-glp1
Oral semaglutide, SNAC absorption, orforglipron and the non-peptide orals.
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246day logs
320participants
19threads
Oral GLP-1 receptor agonists: why oral semaglutide bioavailability is around one percent, what SNAC actually does, the fasting and plain-water rules that almost nobody follows exactly, the PIONEER and OASIS programmes, and the non-peptide orals that do not carry the food restriction.
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Oral semaglutide: plain water only, no more than about half a glass, and nothing else by mouth for 30 minutes. Coffee counts as something. Almost everyone who says it does not work for them is breaking one of these.
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2026-06-29PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses53 msgs · 9 people2026-06-28splitting a dose made the absorption problem worse rather than better in my own log25 msgs · 6 people2026-06-25back after 13 months, has anything changed on the oral side14 msgs · 4 people2026-06-24i was wrong about the water amount, i was using a sip and it needs a lot more than that16 msgs · 5 people2026-06-23is the non peptide thing why orforglipron doesnt need the fasting rules13 msgs · 4 people2026-06-22not a peptide39 msgs · 9 people2026-06-20anyone dosing oral because of a needle problem rather than preference23 msgs · 5 people2026-06-19plain water only20 msgs · 5 people2026-06-18PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses15 msgs · 5 people2026-06-17plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly46 msgs · 13 people2026-06-16went back to injecting14 msgs · 5 people2026-06-15one percent is the number people quote and the spread around it is the actual story52 msgs · 11 people2026-06-12thirty minutes, no cheating14 msgs · 2 people2026-06-11switched from injectable to oral, lost some of the effect, switched back after 19 months the 30 minutes starts when…32 msgs · 7 people2026-06-10right so my weekly log on oral is noisier than my injectable log ever was, same scales same mornings20 msgs · 7 people2026-06-09PIONEER not OASIS27 msgs · 9 people2026-06-08SNAC does the work24 msgs · 7 people2026-06-06unrelated but SNAC raises the local pH and protects it long enough to cross, thats its whole job28 msgs · 7 people2026-06-05whats the bioavailability actually like, i keep seeing about one percent40 msgs · 9 people2026-06-02i keep the tablet by the kettle so i take it before i think about food12 msgs · 4 people2026-05-30why is the oral dose in mg so much bigger than the injectable one22 msgs · 7 people2026-05-29technique probably13 msgs · 3 people2026-05-28went back to injecting because the morning routine was too fragile around shift work, still working it out46 msgs · 12 people2026-05-25lost 25kg over 2 months on oral, slower than my injectable stretch, i stuck with it anyway18 msgs · 5 people2026-05-24set a timer23 msgs · 7 people2026-05-20i take mine at 6am, is 30 minutes really enough53 msgs · 12 people2026-05-17follow up coffee is not plain water. i tried it for a month and my results got worse23 msgs · 4 people2026-05-14i take mine at 6am, is 30 minutes really enough45 msgs · 8 people2026-05-09anyone dosing oral because of a needle problem rather than preference14 msgs · 4 people2026-05-07coffee doesnt count16 msgs · 5 people
Threads spun off from this channel
how long before the oral did anything measurable for2026-06-09 · 9 msgsthe inconsistency is mostly technique and admitting that took2026-05-02 · 16 msgswent back to injecting because the morning routine was2026-03-13 · 11 msgsnobody should copy my morning routine, but the timer2026-03-10 · 9 msgsis the inconsistency people report about the drug or2026-03-01 · 16 msgstook mine with breakfast once by accident and that2026-02-10 · 14 msgssplitting a dose made the absorption problem worse rather2026-02-02 · 13 msgsPIONEER was the original oral semaglutide programme and OASIS2026-01-16 · 12 msgswhy is the oral dose in mg so much2026-01-11 · 11 msgscoming back to this did anyone get consistent results2025-12-13 · 16 msgsanyone dosing oral because of a needle problem rather2025-11-04 · 16 msgsOASIS ran under the same sort of fasting conditions2025-08-31 · 10 msgsquick one the non peptide orals are the interesting2025-08-09 · 15 msgsSNAC raises the local pH and protects it long2025-07-27 · 10 msgsi was wrong about the water amount, i was2025-05-31 · 14 msgsOASIS ran under the same sort of fasting conditions2025-04-26 · 15 msgsone percent is the number people quote and the2025-02-01 · 17 msgsis the inconsistency people report about the drug or2025-01-28 · 9 msgshow long before the oral did anything measurable for2024-10-03 · 5 msgs