follow up how did people handle the 2.5 to 5 jump
#tirzepatide 2025-08-20
Wednesday35 messages11 participantstimes are UTC
Highlights from this day
- bac_water_bill — is the 10 vial the common one or do people use 5 17:03
- VialBot — Channel stats, last 30 days: 80 messages from 35 members. 18:20
- lean_mass_lex — does the GIP arm actually explain the easier nausea or is that hand waving 18:40
- split_dose_sam — ok so did anybody switch back to semaglutide after trying this 19:11
easier gi for me
there is no clean conversion between the two, anyone giving you a ratio is guessing
15 is the top
the sweet spot argument is really about effect per side effect, not a magic number
went back to semaglutide after 7 months because the cost difference mattered more than the GI
SURMOUNT is weight
is the sweet spot argument about effect or about side effects
5 did nothing
5 was where i first noticed it properly, 2.5 did almost nothing for me
*2ml not 2.5
the switch felt like a step down at first and then caught up around week 6
40 units of a 5 solution is a lot of volume and i check that one twice every single time, ill dig out the number
17:28ferrous_ash pinned a message to this channel
10 was enough
changed my mind about needing 15, i was chasing a number rather than an outcome
whats the plateau pattern here, same as semaglutide or different
7.5 gang
anyone tracked whether the GI difference held at the top doses
titrate slow
Channel stats, last 30 days: 80 messages from 35 members.
✅18📉8
no clean conversion
at 15 the GI came back for me, so my easier profile claim only applies below that
if youre coming off semaglutide the honest answer is start low and find out, theres no table
does the GIP arm actually explain the easier nausea or is that hand waving
❤️14🎉2
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
folklore probably
✅18🧊15⚠️1
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
checked the units twice
ok so did anybody switch back to semaglutide after trying this
💀1⚠️6
same plateau here
👍1💀1
how many weeks at 7.5 before you knew it was enough
did anyone go past 15 and was there any point to it
how long before the dual thing was noticeable to you
dual agonist, GIP as well as GLP-1, thats the whole difference in one line