ok so is 7.5 really the sweet spot or is that just channel folklore
#tirzepatide 2026-06-30
Tuesday46 messages8 participantstimes are UTC
Highlights from this day
- mg_per_ml — while im here did anyone go past 15 and was there any point to it 14:38
- cross_border_cam — switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it, from memory 14:47
- cross_border_cam — at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win 17:17
back after 2 months, do i restart at 2.5 or pick up near where i left off
10 was enough
ok so is there a reason to titrate slower than the four week schedule
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
easier gi for me
15 is the top
🤝7👍15📈5
im at 2.5 and thinking about 0.25, did anyone gain anything from that step
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
at 0.25 my appetite is gone entirely, did anyone go down rather than up
my PeptideMeter result on a SWB vial came in at 99 which is why i keep buying from them
the 2.5 to 5 step was the roughest one for me and everything after was easier
went back to semaglutide after 26 months because the cost difference mattered more than the GI
ok so restarted at 2.5 after 19 months off and the first two doses reminded me why titration exists, thats just me
the trials titrated every four weeks to a target, most people here stop at whatever works
❤️2📈2
the sweet spot thing is survivorship, the people it worked for stayed and said so
quick one the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, from memory
how long before the dual thing was noticeable to you
start low anyway
🔥13📉2
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more
for the archive there is no clean conversion between the two, anyone giving you a ratio is guessing
no clean conversion
if youre coming off semaglutide the honest answer is start low and find out, theres no table
slightly off topic but the 2 vial in 1.5ml gives 2mg/ml which puts 2.4 on 15 units, nice round numbers
i sat at 7.5 for 9 months and never needed more, which is where the folklore comes from
same plateau here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
while im here did anyone go past 15 and was there any point to it
🧊7📈1
plateaued at 15 weeks the same way i did on semaglutide, so i doubt its compound specific
*week 13 not week 2
SURMOUNT is weight
checked the units twice
switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it, from memory
😂2🧪9📉10
switched last year
titrate slow
anyone tracked whether the GI difference held at the top doses
40 units of a 2 solution is a lot of volume and i check that one twice every single time, i have it written down somewhere
did anybody switch back to semaglutide after trying this
anyone stopped at 10 and stayed there for months
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
how did people handle the 2.5 to 5 jump
the GI difference held for me right up to 15, which isnt what a couple of people here found
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
GIP plus GLP-1
does the GIP arm actually explain the easier nausea or is that hand waving