plateaued at 16 weeks the same way i did on semaglutide, so i doubt its compound specific
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#tirzepatide 2026-02-10
Tuesday52 messages12 participantstimes are UTC
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follow up did anybody switch back to semaglutide after trying this
genuine question anyone stopped at 10 and stayed there for months
if youre coming off semaglutide the honest answer is start low and find out, theres no table
12 did nothing extra over 10 for me and that still holds a year later
whats the top licensed dose, 15 or does it go higher
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slightly off topic but went back to semaglutide after 24 months because the cost difference mattered more than the GI
switched last year
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, not advice obviously
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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easier gi for me
anyone got a 2.5 recon they like for the 20 vials
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
SURMOUNT is weight
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does the GIP arm actually explain the easier nausea or is that hand waving
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
folklore probably
held 10 for 13 months and lost 46kg over that stretch, slow and boring and fine
the switch felt like a step down at first and then caught up around week 13
*week 24 not week 9
how many weeks at 7.5 before you knew it was enough
start low anyway
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
back after 23 months, do i restart at 2.5 or pick up near where i left off
there is no clean conversion between the two, anyone giving you a ratio is guessing
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the 40 vial in 2ml gives 10mg/ml which puts 2.4 on 50 units, nice round numbers
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restarted at 2.5 after 19 months off and the first two doses reminded me why titration exists
the sweet spot thing is survivorship, the people it worked for stayed and said so
checked the units twice
same plateau here
quick one why does everyone talk about 7.5 and not 10
is there a reason to titrate slower than the four week schedule
40 units of a 10 solution is a lot of volume and i check that one twice every single time
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the sweet spot argument is really about effect per side effect, not a magic number
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i went to 15 and came back to 10, more suppression wasnt more useful for me
the two compounds arent interchangeable week for week even if the effect ends up similar
Reminder for tokyo_taper: dose day is today. Set 8 days ago.
the 2.5 to 5 step was the roughest one for me and everything after was easier
plateaued at 3 weeks the same way i did on semaglutide, so i doubt its compound specific
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
40 units of a 10 solution is a lot of volume and i check that one twice every single time
10 was enough
5 did nothing
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whats the plateau pattern here, same as semaglutide or different
no clean conversion
i sat at 7.5 for 23 months and never needed more, which is where the folklore comes from
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
GIP plus GLP-1
the trials titrated every four weeks to a target, most people here stop at whatever works
while im here how did people handle the 2.5 to 5 jump
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is the sweet spot argument about effect or about side effects
[edited]does the appetite effect feel different or just stronger
7.5 gang
how long before the dual thing was noticeable to you