start low anyway
#tirzepatide 2026-05-19
Tuesday42 messages8 participantstimes are UTC
Highlights from this day
- step_one_sian — dual agonist, GIP as well as GLP-1, thats the whole difference in one line 22:54
- two_three_lifts — i went to 15 and came back to 10, more suppression wasnt more useful for me 23:08
- two_three_lifts — my Janoshik result on a MKM vial came in at 98.6 which is why i keep buying from them, happy to be corrected 23:15
anyone got a 2.5 recon they like for the 20 vials
while im here the trials titrated every four weeks to a target, most people here stop at whatever works
at 15 the GI came back for me, so my easier profile claim only applies below that
GIP plus GLP-1
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anyone stopped at 10 and stayed there for months
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
while im here 40 units of a 4 solution is a lot of volume and i check that one twice every single time
does the GIP arm actually explain the easier nausea or is that hand waving
did anybody switch back to semaglutide after trying this
5 did nothing
is 7.5 really the sweet spot or is that just channel folklore
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
is there a reason to titrate slower than the four week schedule
12 did nothing extra over 10 for me and that still holds a year later
5 was where i first noticed it properly, 2.5 did almost nothing for me
does the appetite effect feel different or just stronger
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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the two compounds arent interchangeable week for week even if the effect ends up similar
the sweet spot argument is really about effect per side effect, not a magic number
update on the earlier thing SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
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im at 10 and thinking about 1.7, did anyone gain anything from that step
7.5 gang
for the archive how long before the dual thing was noticeable to you
i went to 15 and came back to 10, more suppression wasnt more useful for me
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held 10 for 7 months and lost 25kg over that stretch, slow and boring and fine
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at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
my Janoshik result on a MKM vial came in at 98.6 which is why i keep buying from them, happy to be corrected
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
*Janoshik not the other one
Batch lookup E-2205: 9 independent reports on file, earliest 2025-12-28.
plateaued at 17 weeks the same way i did on semaglutide, so i doubt its compound specific
restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists
15 is the top
folklore probably
is the sweet spot argument about effect or about side effects
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
there is no clean conversion between the two, anyone giving you a ratio is guessing
€120 for a 10 vial is roughly what ive paid for the last year
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
switched from 5 semaglutide and started at 2.5, took the slow route, never regretted it
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