switched last year
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#tirzepatide 2026-04-07
Tuesday36 messages7 participantstimes are UTC
Highlights from this day
- peak_split — if youre coming off semaglutide the honest answer is start low and find out, theres no table 20:11
- steady_state_sue — changed my mind about needing 15, i was chasing a number rather than an outcome 20:23
- gip_glp_gil — 5 was where i first noticed it properly, 2.5 did almost nothing for me, thats one data point 21:07
- blank_run — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 22:23
40 units of a 4 solution is a lot of volume and i check that one twice every single time
why does everyone talk about 7.5 and not 10
if youre coming off semaglutide the honest answer is start low and find out, theres no table
🧪5🧊15💀8
did anyone find the GI easier than semaglutide at an equivalent effect
right so at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
no clean conversion
changed my mind about needing 15, i was chasing a number rather than an outcome
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the trials titrated every four weeks to a target, most people here stop at whatever works
7.5 gang
[edited]dual agonist, GIP as well as GLP-1, thats the whole difference in one line
how long before the dual thing was noticeable to you
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update on the earlier thing i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
whats the plateau pattern here, same as semaglutide or different
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, ill dig out the number
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the switch felt like a step down at first and then caught up around week 24
quick one coming off semaglutide, is there a conversion or do i restart at 2.5
follow up i sat at 7.5 for 22 months and never needed more, which is where the folklore comes from
5 was where i first noticed it properly, 2.5 did almost nothing for me, thats one data point
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held 10 for 8 months and lost 25kg over that stretch, slow and boring and fine
the 2.5 to 5 step was the roughest one for me and everything after was easier
5 did nothing
does the appetite effect feel different or just stronger
there is no clean conversion between the two, anyone giving you a ratio is guessing
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i went to 15 and came back to 10, more suppression wasnt more useful for me
went back to semaglutide after 15 months because the cost difference mattered more than the GI
is SURMOUNT-OSA the sleep apnoea one
the sweet spot argument is really about effect per side effect, not a magic number
how did people handle the 2.5 to 5 jump
while im here the sweet spot argument is really about effect per side effect, not a magic number, we shall see
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anyone stopped at 10 and stayed there for months
titrate slow
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
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easier gi for me
SURMOUNT is weight
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genuine question my Janoshik result on a JEEP vial came in at 99 which is why i keep buying from them, happy to be corrected
GIP plus GLP-1