SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
#tirzepatide 2026-02-19
Thursday25 messages5 participantstimes are UTC
Highlights from this day
- no_escrow_nate — the sweet spot argument is really about effect per side effect, not a magic number 10:03
- meal_prep_mick — i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more 10:58
- no_escrow_nate — 5 was where i first noticed it properly, 2.5 did almost nothing for me 12:52
- nausea_window — 40 units of a 2 solution is a lot of volume and i check that one twice every single time 12:55
10 was enough
📈5📉15✅10
7.5 gang
GIP plus GLP-1
💀1🧊1
the two compounds arent interchangeable week for week even if the effect ends up similar
plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
the sweet spot argument is really about effect per side effect, not a magic number
janoshik-a-2601.pdf
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i went to 15 and came back to 10, more suppression wasnt more useful for me
the 2.5 to 5 step was the roughest one for me and everything after was easier
did anyone find the GI easier than semaglutide at an equivalent effect
restarted at 2.5 after 21 months off and the first two doses reminded me why titration exists
i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)whats the top licensed dose, 15 or does it go higher
the switch felt like a step down at first and then caught up around week 5
no gap when i switched, took the last semaglutide dose and started this a week later
is the sweet spot argument about effect or about side effects
the sweet spot thing is survivorship, the people it worked for stayed and said so
is 7.5 really the sweet spot or is that just channel folklore
5 was where i first noticed it properly, 2.5 did almost nothing for me
❤️8
12 did nothing extra over 10 for me and that still holds a year later, i could be wrong
titrate slow
40 units of a 2 solution is a lot of volume and i check that one twice every single time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if youre coming off semaglutide the honest answer is start low and find out, theres no table
Channel stats, last 30 days: 65 messages from 27 members.
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
the GI difference held for me right up to 15, which isnt what a couple of people here found, someone check my working