SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
#tirzepatide 2025-08-10
Sunday58 messages9 participantstimes are UTC
Highlights from this day
- lot_number_lou — my Medutest result on a GL Biochem vial came in at 96.8 which is why i keep buying from them 13:08
- seven_five_sweet — the GI difference held for me right up to 15, which isnt what a couple of people here found, for what its worth 13:57
- electrolyte_eli — 12 did nothing extra over 10 for me and that still holds a year later 15:07
- triumph_watch — for the archive does switching from semaglutide need a gap or do you just start 16:29
at 15 the GI came back for me, so my easier profile claim only applies below that
right so switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
anyone got a 4 recon they like for the 20 vials
*VendorInvestigate not the other one
plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
5 was where i first noticed it properly, 2.5 did almost nothing for me
titrate slow
anyone stopped at 10 and stayed there for months
quick one the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
SURMOUNT is weight
update on the earlier thing changed my mind about needing 15, i was chasing a number rather than an outcome
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
my Medutest result on a GL Biochem vial came in at 96.8 which is why i keep buying from them
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the sweet spot thing is survivorship, the people it worked for stayed and said so
there is no clean conversion between the two, anyone giving you a ratio is guessing
did anyone find the GI easier than semaglutide at an equivalent effect
Inter-lab diff for lot C-4402: 98.1% vs 99%. Within expected range.
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sorry to jump in €55 for a 20 vial is roughly what ive paid for the last year
i went to 15 and came back to 10, more suppression wasnt more useful for me
coming back to this went back to semaglutide after 25 months because the cost difference mattered more than the GI
the 2.5 to 5 step was the roughest one for me and everything after was easier
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from
[edited]the GI difference held for me right up to 15, which isnt what a couple of people here found, for what its worth
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held 10 for 20 months and lost 7kg over that stretch, slow and boring and fine, n of 1 obviously
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the switch felt like a step down at first and then caught up around week 13
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does the GIP arm actually explain the easier nausea or is that hand waving
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the trials titrated every four weeks to a target, most people here stop at whatever works
at 1 my appetite went completely and i dropped back a step, eating nothing isnt a win
did anybody switch back to semaglutide after trying this
ok so is SURMOUNT-OSA the sleep apnoea one
anyone tracked whether the GI difference held at the top doses
40 units of a 8 solution is a lot of volume and i check that one twice every single time
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12 did nothing extra over 10 for me and that still holds a year later
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5 did nothing
no clean conversion, ill dig out the number
why does everyone talk about 7.5 and not 10
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
is there a reason to titrate slower than the four week schedule
coming off semaglutide, is there a conversion or do i restart at 2.5
genuine question is the sweet spot argument about effect or about side effects
did anyone go past 15 and was there any point to it
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
for the archive does switching from semaglutide need a gap or do you just start
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10 was enough
the sweet spot argument is really about effect per side effect, not a magic number
how long before the dual thing was noticeable to you
restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists
*PeptideMeter not the other one
folklore probably
the 30 vial in 2ml gives 5mg/ml which puts 10 on 30 units, nice round numbers
no gap when i switched, took the last semaglutide dose and started this a week later
i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more
SURMOUNT-1 versus SURPASS-2, which one was the weight trial