how many weeks at 7.5 before you knew it was enough
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
#tirzepatide 2026-05-09
Saturday58 messages10 participantstimes are UTC
Highlights from this day
- gus_charts — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 22:00
- bo_bloodwork — slightly off topic but is 7.5 really the sweet spot or is that just channel folklore 22:22
- vale_vials — i argued the sweet spot was nonsense and then spent 20 months at 7.5 not needing more 22:59
- chlorhex — changed my mind about needing 15, i was chasing a number rather than an outcome 23:58
the sweet spot argument is really about effect per side effect, not a magic number
whats the top licensed dose, 15 or does it go higher
40 units of a 5 solution is a lot of volume and i check that one twice every single time
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
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restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
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GIP plus GLP-1
did anybody switch back to semaglutide after trying this
checked the units twice
is the sweet spot argument about effect or about side effects
changed my mind about needing 15, i was chasing a number rather than an outcome
held 10 for 26 months and lost 17kg over that stretch, slow and boring and fine
went back to semaglutide after 10 months because the cost difference mattered more than the GI, happy to be corrected
the trials titrated every four weeks to a target, most people here stop at whatever works
if youre coming off semaglutide the honest answer is start low and find out, theres no table
12 did nothing extra over 10 for me and that still holds a year later
did anyone find the GI easier than semaglutide at an equivalent effect
slightly off topic but is 7.5 really the sweet spot or is that just channel folklore
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im at 0.5 and thinking about 12, did anyone gain anything from that step
fridge-temps.csv
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the GI difference held for me right up to 15, which isnt what a couple of people here found
my Medutest result on a QYB vial came in at 99 which is why i keep buying from them
10 was enough
at 15 the GI came back for me, so my easier profile claim only applies below that
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
anyone stopped at 10 and stayed there for months
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why does everyone talk about 7.5 and not 10
the 10 vial in 2.5ml gives 2mg/ml which puts 2 on 40 units, nice round numbers
update on the earlier thing if youre coming off semaglutide the honest answer is start low and find out, theres no table
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folklore probably
did going from 12 semaglutide to 5 of this feel like a step down for anyone
unrelated but held 10 for 5 months and lost 27kg over that stretch, slow and boring and fine
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from
is there a reason to titrate slower than the four week schedule
titrate slow
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
7.5 gang
no clean conversion
i argued the sweet spot was nonsense and then spent 20 months at 7.5 not needing more
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whats the plateau pattern here, same as semaglutide or different
the 2.5 to 5 step was the roughest one for me and everything after was easier
[edited]start low anyway
SURMOUNT is weight
the switch felt like a step down at first and then caught up around week 17
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, ymmv
no gap when i switched, took the last semaglutide dose and started this a week later
right so i went to 15 and came back to 10, more suppression wasnt more useful for me
5 was where i first noticed it properly, 2.5 did almost nothing for me
does switching from semaglutide need a gap or do you just start
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
nhs_pathway_nellunrelated but held 10 for 5 months and lost 27kg over that stretch, slow and boring…
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
same plateau here
nhs_pathway_nellunrelated but held 10 for 5 months and lost 27kg over that stretch, slow and boring…
back after 26 months, do i restart at 2.5 or pick up near where i left off
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the two compounds arent interchangeable week for week even if the effect ends up similar
the switch felt like a step down at first and then caught up around week 13
7.5 gang, thats just me
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
£185 for a 40 vial is roughly what ive paid for the last year
changed my mind about needing 15, i was chasing a number rather than an outcome
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