the switch felt like a step down at first and then caught up around week 28
#tirzepatide 2026-04-22
Wednesday54 messages10 participantstimes are UTC
Highlights from this day
- tokyo_taper — i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more 21:18
- peak_split — coming off semaglutide, is there a conversion or do i restart at 2.5 21:53
- peak_split — did anybody switch back to semaglutide after trying this 21:58
- stack_sceptic — at 15 the GI came back for me, so my easier profile claim only applies below that 22:23
- tokyo_taper — anyone got a 2.5 recon they like for the 2 vials 22:45
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
how did people handle the 2.5 to 5 jump
i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more
weights-monthly.csv
279 rows · not retained in the public archive
checked the units twice
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10 was enough
the trials titrated every four weeks to a target, most people here stop at whatever works
how many weeks at 7.5 before you knew it was enough
did anyone find the GI easier than semaglutide at an equivalent effect
is the sweet spot argument about effect or about side effects
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
titrate slow
[edited]is there a reason to titrate slower than the four week schedule
does the GIP arm actually explain the easier nausea or is that hand waving
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the 30 vial in 0.5ml gives 8mg/ml which puts 1 on 30 units, nice round numbers
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ask me again in a month
ok so GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
did anyone go past 15 and was there any point to it
€185 for a 40 vial is roughly what ive paid for the last year
update on the earlier thing the GI difference held for me right up to 15, which isnt what a couple of people here found
15 is the top
coming off semaglutide, is there a conversion or do i restart at 2.5
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no gap when i switched, took the last semaglutide dose and started this a week later
[edited]did anybody switch back to semaglutide after trying this
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unrelated but there is no clean conversion between the two, anyone giving you a ratio is guessing
went back to semaglutide after 21 months because the cost difference mattered more than the GI
i went to 15 and came back to 10, more suppression wasnt more useful for me
changed my mind about needing 15, i was chasing a number rather than an outcome
switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
5 did nothing
start low anyway
sorry to jump in anyone stopped at 10 and stayed there for months
the trials titrated every four weeks to a target, most people here stop at whatever works
at 15 the GI came back for me, so my easier profile claim only applies below that
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)whats the top licensed dose, 15 or does it go higher
the 2.5 to 5 step was the roughest one for me and everything after was easier
*2ml not 2.5
did going from 10 semaglutide to 5 of this feel like a step down for anyone
the sweet spot thing is survivorship, the people it worked for stayed and said so, take that with a pinch of salt
im at 0.5 and thinking about 5, did anyone gain anything from that step
plateaued at 16 weeks the same way i did on semaglutide, so i doubt its compound specific
switched last year
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists
anyone got a 2.5 recon they like for the 2 vials
the two compounds arent interchangeable week for week even if the effect ends up similar
easier gi for me
ok so the sweet spot argument is really about effect per side effect, not a magic number
7.5 gang
[edited]40 units of a 4 solution is a lot of volume and i check that one twice every single time
update on the earlier thing does switching from semaglutide need a gap or do you just start
[edited]same plateau here
is 7.5 really the sweet spot or is that just channel folklore
no clean conversion
is the 5 vial the common one or do people use 10
is SURMOUNT-OSA the sleep apnoea one
12 did nothing extra over 10 for me and that still holds a year later