went back to semaglutide after 22 months because the cost difference mattered more than the GI
#tirzepatide 2026-06-16
Tuesday53 messages14 participantstimes are UTC
Highlights from this day
- area_percent — 5 was where i first noticed it properly, 2.5 did almost nothing for me 19:23
- area_percent — at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win 19:33
- sgp_subq — my PeptideMeter result on a ERP vial came in at 98.6 which is why i keep buying from them 19:43
*PeptideMeter not the other one
same plateau here
peptidemeter-summary-h-2814.pdf
2 pages · 795 KB · not retained in the public archive
restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists
folklore probably
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checked the units twice
coming back to this whats the top licensed dose, 15 or does it go higher
how long before the dual thing was noticeable to you
plateaued at 17 weeks the same way i did on semaglutide, so i doubt its compound specific
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
coming back to this anyone tracked whether the GI difference held at the top doses
does switching from semaglutide need a gap or do you just start
no gap when i switched, took the last semaglutide dose and started this a week later, we shall see
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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how many weeks at 7.5 before you knew it was enough
the 2.5 to 5 step was the roughest one for me and everything after was easier
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5 was where i first noticed it properly, 2.5 did almost nothing for me
lot-log.csv
192 rows · not retained in the public archive
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whats the plateau pattern here, same as semaglutide or different
start low anyway
the two compounds arent interchangeable week for week even if the effect ends up similar
at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
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12 did nothing extra over 10 for me and that still holds a year later
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did anyone find the GI easier than semaglutide at an equivalent effect
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my PeptideMeter result on a ERP vial came in at 98.6 which is why i keep buying from them
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
GIP plus GLP-1
40 units of a 8 solution is a lot of volume and i check that one twice every single time
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switched last year
anyone got a 2.5 recon they like for the 30 vials
did going from 5 semaglutide to 5 of this feel like a step down for anyone
the 20 vial in 1.5ml gives 4mg/ml which puts 5 on 15 units, nice round numbers
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*PeptideMeter not the other one
did anybody switch back to semaglutide after trying this
15 is the top
5 did nothing
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
no clean conversion
SURMOUNT is weight
back after 19 months, do i restart at 2.5 or pick up near where i left off
is 7.5 really the sweet spot or is that just channel folklore
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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the sweet spot thing is survivorship, the people it worked for stayed and said so, still working it out
10 was enough
there is no clean conversion between the two, anyone giving you a ratio is guessing
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7.5 gang
titrate slow
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is the 5 vial the common one or do people use 15
is there a reason to titrate slower than the four week schedule
the GI difference held for me right up to 15, which isnt what a couple of people here found, i have it written down somewhere
anyone stopped at 10 and stayed there for months
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
no clean conversion
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if youre coming off semaglutide the honest answer is start low and find out, theres no table