same plateau here
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#tirzepatide 2025-10-03
Friday35 messages5 participantstimes are UTC
Highlights from this day
- lurker_lu — no gap when i switched, took the last semaglutide dose and started this a week later 18:50
- lurker_lu — there is no clean conversion between the two, anyone giving you a ratio is guessing 19:04
- surpass_two — the GI difference held for me right up to 15, which isnt what a couple of people here found, thats one data point 21:09
- surpass_two — i sat at 7.5 for 2 months and never needed more, which is where the folklore comes from 21:22
the switch felt like a step down at first and then caught up around week 24
*week 3 not week 7
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
why does everyone talk about 7.5 and not 10
slightly off topic but my Janoshik result on a SGN vial came in at 99.2 which is why i keep buying from them, i have it written down somewhere
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
checked the units twice
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
40 units of a 5 solution is a lot of volume and i check that one twice every single time
the 5 vial in 5ml gives 2.5mg/ml which puts 1.7 on 30 units, nice round numbers
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
no gap when i switched, took the last semaglutide dose and started this a week later
📉10
there is no clean conversion between the two, anyone giving you a ratio is guessing
whats the top licensed dose, 15 or does it go higher
right so restarted at 2.5 after 5 months off and the first two doses reminded me why titration exists
folklore probably
€72 for a 10 vial is roughly what ive paid for the last year
does switching from semaglutide need a gap or do you just start
if youre coming off semaglutide the honest answer is start low and find out, theres no table
how did people handle the 2.5 to 5 jump
📉1
5 was where i first noticed it properly, 2.5 did almost nothing for me
🧊4
10 was enough
📈1
back after 13 months, do i restart at 2.5 or pick up near where i left off
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
[edited]for the archive licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
start low anyway
anyone tracked whether the GI difference held at the top doses
plateaued at 3 weeks the same way i did on semaglutide, so i doubt its compound specific
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
the GI difference held for me right up to 15, which isnt what a couple of people here found, thats one data point
✅3⚠️17💀14
*that should say weekly
no clean conversion
💀2
i sat at 7.5 for 2 months and never needed more, which is where the folklore comes from
i went to 15 and came back to 10, more suppression wasnt more useful for me
is the sweet spot argument about effect or about side effects