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#maintenance
After the loss. Dose reduction, regain, and whether this is forever.
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The part of this that gets the least attention and matters the most: reducing to a maintenance dose versus staying at a treatment dose, what STEP 4 implies about stopping, regain and returning, lower-frequency maintenance and the complete absence of trial data for it, and holding lean mass.
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STEP 4 (JAMA 2021) is the trial about stopping. Read it before you plan an exit. The regain in the withdrawal arm was not subtle.
Lower-frequency maintenance dosing has no trial behind it. People here do it and report on it. That is data, but it is not evidence.
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2026-06-28how do people handle a two week holiday at a maintenance dose27 msgs · 6 people2026-06-26regain is expected17 msgs · 5 people2026-06-25lower frequency maintenance is genuinely unstudied. anybody telling you it is proven is making that up38 msgs · 10 people2026-06-24weekly not daily12 msgs · 3 people2026-06-20two or three kilos up and down is normal fluctuation. ten is a different conversation55 msgs · 11 people2026-06-18there is no official maintenance dose. it is a thing we do because the alternative on the table was stopping, ymmv16 msgs · 3 people2026-06-17maintenance is harder than losing because there is no number going down to keep you interested12 msgs · 4 people2026-06-16went back up, no regrets44 msgs · 10 people2026-06-12harder than losing41 msgs · 10 people2026-06-11while im here does anyone lift specifically to hold onto muscle now that theyre maintaining26 msgs · 6 people2026-06-10slightly off topic but regain after stopping is the expected outcome, which is a horrible sentence and also what the…22 msgs · 6 people2026-06-09i came off for four months, put 16 back on, and came back. no drama in it, just numbers, your mileage will differ22 msgs · 7 people2026-06-06went back up, no regrets32 msgs · 8 people2026-06-05went back up, no regrets38 msgs · 8 people2026-06-01the maintenance conversation barely existed in here two years ago and now it is half the channel50 msgs · 12 people2026-05-28New independent result logged — WXT, lot A-2418, purity 98.6% (VendorInvestigate).25 msgs · 9 people2026-05-27regain is expected55 msgs · 11 people2026-05-25did anyone drop the dose for maintenance or just stay where they were13 msgs · 3 people2026-05-24no data on that45 msgs · 11 people2026-05-23i put 24 back on after stopping and then went back on it. it worked the same the second time round, thats just me13 msgs · 3 people2026-05-22Testing queue: 8 submissions open, 60 awaiting dispatch.42 msgs · 10 people2026-05-21is maintenance different between semaglutide and the others or is that all anecdote51 msgs · 11 people2026-05-20my range is 43 and i stopped calling anything inside that a regain27 msgs · 9 people2026-05-19quick one stopped 11 months ago and put 20 back on, what did people do at that point35 msgs · 8 people2026-05-17two or three kilos up and down is normal fluctuation. ten is a different conversation51 msgs · 11 people2026-05-16did anyone regret dropping the dose too fast54 msgs · 13 people2026-05-15how much regain did people get in the first 9 months after stopping18 msgs · 2 people2026-05-14coming back after 8 months of maintenance, is anyone interested in the numbers54 msgs · 11 people2026-05-13unrelated but i weigh weekly at maintenance rather than daily and my range is about two kilos either side46 msgs · 11 people2026-05-10resistance training two or three times a week is what the room converged on and it is not glamorous13 msgs · 4 people
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update from 16 months ago: still at maintenance, still2026-06-16 · 16 msgsfollow up i went to every ten days at2026-05-28 · 15 msgswhy fortnightly dosing is pharmacologically odd but not absurd2026-04-26 · 6 msgsi set a trigger weight instead of a target2026-04-14 · 13 msgsthere is no official maintenance dose. it is a2026-01-24 · 16 msgsthe food noise came back at the lower dose2025-11-22 · 15 msgstwo or three kilos up and down is normal2025-11-11 · 13 msgsim holding at 1.7 for maintenance and wondering whether2025-10-21 · 15 msgsupdate on the earlier thing the muscle question is2025-10-18 · 10 msgsi was wrong about maintenance being the easy part2025-09-14 · 7 msgsresistance training two or three times a week is2025-06-15 · 7 msgsdoes anyone budget for maintenance being cheaper or is2025-05-02 · 10 msgshow quickly did appetite come back going from 7.52025-04-16 · 10 msgs