start low anyway
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#tirzepatide 2025-08-23
Saturday62 messages12 participantstimes are UTC
Highlights from this day
- red_flag_ruby — the sweet spot thing is survivorship, the people it worked for stayed and said so 5 was where i first noticed it properly, 2.5 did almost nothing for me 19:16
- still_here_2024 — 12 did nothing extra over 10 for me and that still holds a year later 20:30
- dana_titrates — there is no clean conversion between the two, anyone giving you a ratio is guessing 21:19
- same_chromato — the two compounds arent interchangeable week for week even if the effect ends up similar 22:00
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, ill dig out the number
GIP plus GLP-1
the switch felt like a step down at first and then caught up around week 27
SURMOUNT is weight
Purity check: no report on file for lot SG-1177. Nothing logged either way.
at 15 the GI came back for me, so my easier profile claim only applies below that
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, someone check my working
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slightly off topic but i went to 15 and came back to 10, more suppression wasnt more useful for me
anyone tracked whether the GI difference held at the top doses
sorry to jump in does the GIP arm actually explain the easier nausea or is that hand waving
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the sweet spot thing is survivorship, the people it worked for stayed and said so
5 was where i first noticed it properly, 2.5 did almost nothing for me
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no clean conversion
titrate slow
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folklore probably
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the sweet spot argument is really about effect per side effect, not a magic number
easier gi for me
does switching from semaglutide need a gap or do you just start
did anyone find the GI easier than semaglutide at an equivalent effect
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, i could be wrong
40 units of a 10 solution is a lot of volume and i check that one twice every single time
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
went back to semaglutide after 21 months because the cost difference mattered more than the GI
fridge-temps.csv
734 rows · not retained in the public archive
is the 40 vial the common one or do people use 15
switched last year
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
7.5 gang
Reminder for vienna_vial: dose day is today. Set 8 days ago.
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is 7.5 really the sweet spot or is that just channel folklore
£38 for a 10 vial is roughly what ive paid for the last year
10 was enough
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the 2.5 to 5 step was the roughest one for me and everything after was easier
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12 did nothing extra over 10 for me and that still holds a year later
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)did anyone go past 15 and was there any point to it
quick one how many weeks at 7.5 before you knew it was enough
does the appetite effect feel different or just stronger
did going from 0.5 semaglutide to 5 of this feel like a step down for anyone
checked the units twice
5 did nothing
15 is the top
is there a reason to titrate slower than the four week schedule
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
back after 21 months, do i restart at 2.5 or pick up near where i left off
the 2 vial in 2ml gives 10mg/ml which puts 15 on 12 units, nice round numbers
for the archive is SURMOUNT-OSA the sleep apnoea one
i argued the sweet spot was nonsense and then spent 16 months at 7.5 not needing more, happy to be corrected
12 did nothing extra over 10 for me and that still holds a year later
there is no clean conversion between the two, anyone giving you a ratio is guessing
[edited]wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)plateaued at 29 weeks the same way i did on semaglutide, so i doubt its compound specific, take that with a pinch of salt
my Janoshik result on a QST vial came in at 99 which is why i keep buying from them, from memory
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from
coming back to this held 10 for 24 months and lost 16kg over that stretch, slow and boring and fine
anyone got a 8 recon they like for the 2 vials
changed my mind about needing 15, i was chasing a number rather than an outcome, take that with a pinch of salt
15 is the top
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the two compounds arent interchangeable week for week even if the effect ends up similar
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5 was where i first noticed it properly, 2.5 did almost nothing for me
unrelated but 10 was enough
[edited]at 1 my appetite is gone entirely, did anyone go down rather than up
same plateau here
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
40 units of a 10 solution is a lot of volume and i check that one twice every single time
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