changed my mind about needing 15, i was chasing a number rather than an outcome
#tirzepatide 2025-09-07
Sunday26 messages5 participantstimes are UTC
Highlights from this day
- lyophile_liv — genuine question the GI difference held for me right up to 15, which isnt what a couple of people here found 16:10
- lot_number_lou — the switch felt like a step down at first and then caught up around week 2, n of 1 obviously 17:57
- site_itch — my Janoshik result on a MKM vial came in at 98.6 which is why i keep buying from them 12 did nothing extra over 10 for me and that still holds a year later 18:55
- lot_number_lou — did anyone find the GI easier than semaglutide at an equivalent effect 19:12
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
anyone tracked whether the GI difference held at the top doses
im at 2.5 and thinking about 1.7, did anyone gain anything from that step
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists
genuine question the GI difference held for me right up to 15, which isnt what a couple of people here found
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
15 is the top
does the appetite effect feel different or just stronger
held 10 for 15 months and lost 28kg over that stretch, slow and boring and fine
*that should say weekly
Inter-lab diff for lot D-0718: 96.8% vs 97.4%. Within expected range.
at 15 the GI came back for me, so my easier profile claim only applies below that
the switch felt like a step down at first and then caught up around week 2, n of 1 obviously
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quick one SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
SURMOUNT is weight
switched last year
my Janoshik result on a MKM vial came in at 98.6 which is why i keep buying from them
12 did nothing extra over 10 for me and that still holds a year later
checked the units twice
did anyone find the GI easier than semaglutide at an equivalent effect
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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