the sweet spot thing is survivorship, the people it worked for stayed and said so, i could be wrong
[edited]#tirzepatide 2025-09-06
Saturday54 messages14 participantstimes are UTC
Highlights from this day
- lean_mass_lex — at 0.25 my appetite is gone entirely, did anyone go down rather than up 19:36
- reta_resting_hr — the GI difference held for me right up to 15, which isnt what a couple of people here found, i think 20:01
- cricket_or_footy — held 10 for 14 months and lost 7kg over that stretch, slow and boring and fine, i think 20:39
the 2.5 to 5 step was the roughest one for me and everything after was easier
no clean conversion
💀17
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the 15 vial in 2.5ml gives 4mg/ml which puts 1 on 20 units, nice round numbers
does switching from semaglutide need a gap or do you just start
is SURMOUNT-OSA the sleep apnoea one
did going from 15 semaglutide to 5 of this feel like a step down for anyone
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
💀4
changed my mind about needing 15, i was chasing a number rather than an outcome, ask me again in a month
🎉10
16:44ferrous_ash pinned a message
is the 10 vial the common one or do people use 40
my VendorInvestigate result on a TFC vial came in at 98.6 which is why i keep buying from them
GIP plus GLP-1
while im here is 7.5 really the sweet spot or is that just channel folklore
there is no clean conversion between the two, anyone giving you a ratio is guessing
anyone got a 2.5 recon they like for the 40 vials
i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more
did anyone go past 15 and was there any point to it
follow up coming off semaglutide, is there a conversion or do i restart at 2.5
🧪12😂4
folklore probably
⚠️1👍14
switched last year
📉18
follow up the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i think
genuine question SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
anyone stopped at 10 and stayed there for months
💀10
5 was where i first noticed it properly, 2.5 did almost nothing for me
i went to 15 and came back to 10, more suppression wasnt more useful for me, your mileage will differ
back after 21 months, do i restart at 2.5 or pick up near where i left off
is the sweet spot argument about effect or about side effects
same plateau here
does the appetite effect feel different or just stronger
titrate slow
the two compounds arent interchangeable week for week even if the effect ends up similar
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
did anyone find the GI easier than semaglutide at an equivalent effect
does the GIP arm actually explain the easier nausea or is that hand waving
how long before the dual thing was noticeable to you
i sat at 7.5 for 8 months and never needed more, which is where the folklore comes from
at 0.25 my appetite is gone entirely, did anyone go down rather than up
🔥15⚠️10❤️10
10 was enough
the GI difference held for me right up to 15, which isnt what a couple of people here found, i think
[edited]⚠️16
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
held 10 for 14 months and lost 7kg over that stretch, slow and boring and fine, i think
🎉1👍7🧪17
restarted at 2.5 after 1 months off and the first two doses reminded me why titration exists
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
12 did nothing extra over 10 for me and that still holds a year later, still working it out
[edited]start low anyway
how many weeks at 7.5 before you knew it was enough
ok so no gap when i switched, took the last semaglutide dose and started this a week later
5 was where i first noticed it properly, 2.5 did almost nothing for me
15 is the top
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