12 did nothing extra over 10 for me and that still holds a year later
#tirzepatide 2025-10-02
Thursday40 messages8 participantstimes are UTC
Highlights from this day
- ruo_only — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 20:33
- ruo_only — i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from 20:43
- lead_time_lars — went back to semaglutide after 14 months because the cost difference mattered more than the GI 21:06
- lead_time_lars — £94 for a 40 vial is roughly what ive paid for the last year 21:08
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, thats just me
did anyone go past 15 and was there any point to it
restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists
the two compounds arent interchangeable week for week even if the effect ends up similar
held 10 for 16 months and lost 36kg over that stretch, slow and boring and fine
lead_time_larsdual agonist, GIP as well as GLP-1, thats the whole difference in one line, thats just…
40 units of a 4 solution is a lot of volume and i check that one twice every single time
is SURMOUNT-OSA the sleep apnoea one
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the GI difference held for me right up to 15, which isnt what a couple of people here found
im at 2 and thinking about 10, did anyone gain anything from that step
GIP plus GLP-1
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there is no clean conversion between the two, anyone giving you a ratio is guessing
does the GIP arm actually explain the easier nausea or is that hand waving
whats the plateau pattern here, same as semaglutide or different
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming off semaglutide, is there a conversion or do i restart at 2.5
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*2ml not 2.5
15 is the top
does the appetite effect feel different or just stronger
the 20 vial in 1ml gives 10mg/ml which puts 2 on 25 units, nice round numbers
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
🤝5❤️17📉8
i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from
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ok so i argued the sweet spot was nonsense and then spent 4 months at 7.5 not needing more, i think
the two compounds arent interchangeable week for week even if the effect ends up similar
titrate slow
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while im here back after 4 months, do i restart at 2.5 or pick up near where i left off
went back to semaglutide after 14 months because the cost difference mattered more than the GI
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
£94 for a 40 vial is roughly what ive paid for the last year
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anyone stopped at 10 and stayed there for months
Inter-lab diff for lot C-4402: 99.4% vs 98.1%. Within expected range.
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
40 units of a 5 solution is a lot of volume and i check that one twice every single time
at 1.7 my appetite is gone entirely, did anyone go down rather than up
is 7.5 really the sweet spot or is that just channel folklore
checked the units twice
[edited]5 did nothing
does switching from semaglutide need a gap or do you just start
coming back to this my Medutest result on a TFC vial came in at 99.4 which is why i keep buying from them, thats one data point
the sweet spot argument is really about effect per side effect, not a magic number
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
no clean conversion
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7.5 gang