update on the earlier thing £240 for a 2 vial is roughly what ive paid for the last year
#tirzepatide 2025-09-05
Friday44 messages10 participantstimes are UTC
Highlights from this day
- bea_reconstitutes — the GI difference held for me right up to 15, which isnt what a couple of people here found, your mileage will differ 15:12
- bea_reconstitutes — at 15 the GI came back for me, so my easier profile claim only applies below that 15:19
- gradient_greg — does the appetite effect feel different or just stronger 19:17
7.5 gang
if youre coming off semaglutide the honest answer is start low and find out, theres no table
GIP plus GLP-1
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
no gap when i switched, took the last semaglutide dose and started this a week later
titrate slow
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the switch felt like a step down at first and then caught up around week 11
how long before the dual thing was noticeable to you
12 did nothing extra over 10 for me and that still holds a year later, your mileage will differ
the sweet spot thing is survivorship, the people it worked for stayed and said so, from memory
the GI difference held for me right up to 15, which isnt what a couple of people here found, your mileage will differ
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at 15 the GI came back for me, so my easier profile claim only applies below that
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, n of 1 obviously
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did anyone find the GI easier than semaglutide at an equivalent effect
why does everyone talk about 7.5 and not 10
changed my mind about needing 15, i was chasing a number rather than an outcome, anyway
unrelated but the 10 vial in 2ml gives 2.5mg/ml which puts 2.4 on 12 units, nice round numbers, for what its worth
no clean conversion
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
ok so is SURMOUNT-OSA the sleep apnoea one
5 was where i first noticed it properly, 2.5 did almost nothing for me
follow up does the GIP arm actually explain the easier nausea or is that hand waving
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)did anyone go past 15 and was there any point to it
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folklore probably
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15 is the top
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held 10 for 11 months and lost 35kg over that stretch, slow and boring and fine
does switching from semaglutide need a gap or do you just start
is the sweet spot argument about effect or about side effects
for the archive whats the top licensed dose, 15 or does it go higher
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40 units of a 5 solution is a lot of volume and i check that one twice every single time
*that should say weekly
did anybody switch back to semaglutide after trying this
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my VendorInvestigate result on a JEEP vial came in at 99 which is why i keep buying from them, ymmv
the trials titrated every four weeks to a target, most people here stop at whatever works
went back to semaglutide after 9 months because the cost difference mattered more than the GI
whats the plateau pattern here, same as semaglutide or different
does the appetite effect feel different or just stronger
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anyone tracked whether the GI difference held at the top doses
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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SURMOUNT is weight
is the 5 vial the common one or do people use 30
same plateau here