the trials titrated every four weeks to a target, most people here stop at whatever works
#tirzepatide 2026-01-18
Sunday62 messages14 participantstimes are UTC
Highlights from this day
update on the earlier thing the sweet spot argument is really about effect per side effect, not a magic number
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line, n of 1 obviously
is the sweet spot argument about effect or about side effects
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the switch felt like a step down at first and then caught up around week 27
unrelated but at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
the 2.5 to 5 step was the roughest one for me and everything after was easier
at 15 the GI came back for me, so my easier profile claim only applies below that
$72 for a 40 vial is roughly what ive paid for the last year
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
update on the earlier thing anyone got a 2.5 recon they like for the 20 vials
did going from 5 semaglutide to 5 of this feel like a step down for anyone
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did anybody switch back to semaglutide after trying this
for the archive how many weeks at 7.5 before you knew it was enough
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
does switching from semaglutide need a gap or do you just start
same plateau here
right so if youre coming off semaglutide the honest answer is start low and find out, theres no table
there is no clean conversion between the two, anyone giving you a ratio is guessing
right so the sweet spot thing is survivorship, the people it worked for stayed and said so, thats just me
no gap when i switched, took the last semaglutide dose and started this a week later
changed my mind about needing 15, i was chasing a number rather than an outcome
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my PeptideMeter result on a TFC vial came in at 96.8 which is why i keep buying from them
easier gi for me
is there a reason to titrate slower than the four week schedule
anyone tracked whether the GI difference held at the top doses
im at 0.25 and thinking about 2.5, did anyone gain anything from that step
switched last year
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held 10 for 23 months and lost 3kg over that stretch, slow and boring and fine, happy to be corrected
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, still working it out
how did people handle the 2.5 to 5 jump
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genuine question the two compounds arent interchangeable week for week even if the effect ends up similar, ymmv
whats the plateau pattern here, same as semaglutide or different
anyone stopped at 10 and stayed there for months
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15 is the top
Digest for the week of 2025-03-20 has been published.
7.5 gang
40 units of a 8 solution is a lot of volume and i check that one twice every single time
at 1.7 my appetite is gone entirely, did anyone go down rather than up
the 5 vial in 2ml gives 10mg/ml which puts 0.25 on 40 units, nice round numbers, ymmv
SURMOUNT is weight
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how long before the dual thing was noticeable to you
genuine question 5 was where i first noticed it properly, 2.5 did almost nothing for me
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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coming off semaglutide, is there a conversion or do i restart at 2.5
unrelated but i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
why does everyone talk about 7.5 and not 10
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start low anyway
is 7.5 really the sweet spot or is that just channel folklore
i argued the sweet spot was nonsense and then spent 25 months at 7.5 not needing more
no clean conversion
10 was enough
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folklore probably
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i went to 15 and came back to 10, more suppression wasnt more useful for me
GIP plus GLP-1
the GI difference held for me right up to 15, which isnt what a couple of people here found
went back to semaglutide after 26 months because the cost difference mattered more than the GI
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is the 2 vial the common one or do people use 20
did anyone find the GI easier than semaglutide at an equivalent effect
did anyone go past 15 and was there any point to it
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
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