GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
#tirzepatide 2026-06-15
Monday72 messages12 participantstimes are UTC
Highlights from this day
- thirty_one_g — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 12:11
- provincial_pat — 5 was where i first noticed it properly, 2.5 did almost nothing for me 14:42
- VialBot — Verification log updated: QSC — evidence added, status unchanged. 17:13
- triumph_watch — is the sweet spot argument about effect or about side effects 17:52
- logrotate — anyone got a 2 recon they like for the 15 vials 18:41
right so restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
the two compounds arent interchangeable week for week even if the effect ends up similar
genuine question switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
changed my mind about needing 15, i was chasing a number rather than an outcome, anyway
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15 is the top
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did going from 1 semaglutide to 5 of this feel like a step down for anyone
my Janoshik result on a QSC vial came in at 96.8 which is why i keep buying from them
i argued the sweet spot was nonsense and then spent 5 months at 7.5 not needing more
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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coming back to this there is no clean conversion between the two, anyone giving you a ratio is guessing
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, your mileage will differ
the sweet spot thing is survivorship, the people it worked for stayed and said so
40 units of a 2 solution is a lot of volume and i check that one twice every single time
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
10 was enough
the sweet spot argument is really about effect per side effect, not a magic number
GIP plus GLP-1
for the archive SURMOUNT-1 versus SURPASS-2, which one was the weight trial
if youre coming off semaglutide the honest answer is start low and find out, theres no table
[edited]same plateau here
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checked the units twice
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quick one held 10 for 7 months and lost 42kg over that stretch, slow and boring and fine, from memory
start low anyway
titrate slow
$185 for a 10 vial is roughly what ive paid for the last year
changed my mind about needing 15, i was chasing a number rather than an outcome
the 2.5 to 5 step was the roughest one for me and everything after was easier
whats the plateau pattern here, same as semaglutide or different
back after 22 months, do i restart at 2.5 or pick up near where i left off
no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me
5 was where i first noticed it properly, 2.5 did almost nothing for me
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
easier gi for me
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Inter-lab diff for lot D-0718: 97.4% vs 96.8%. Within expected range.
5 did nothing
folklore probably
how many weeks at 7.5 before you knew it was enough
SURMOUNT is weight
sorry to jump in went back to semaglutide after 3 months because the cost difference mattered more than the GI
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does the appetite effect feel different or just stronger
the GI difference held for me right up to 15, which isnt what a couple of people here found
7.5 gang, from memory
plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
*Janoshik not the other one
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the trials titrated every four weeks to a target, most people here stop at whatever works
did anyone go past 15 and was there any point to it
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more
sorry to jump in no gap when i switched, took the last semaglutide dose and started this a week later
the two compounds arent interchangeable week for week even if the effect ends up similar
for the archive does switching from semaglutide need a gap or do you just start
Verification log updated: QSC — evidence added, status unchanged.
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did anybody switch back to semaglutide after trying this
switched last year
[edited]12 did nothing extra over 10 for me and that still holds a year later
at 15 the GI came back for me, so my easier profile claim only applies below that
easier gi for me
5 did nothing, not advice obviously
7.5 gang
anyone stopped at 10 and stayed there for months
is the sweet spot argument about effect or about side effects
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
unrelated but how long before the dual thing was noticeable to you
i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the switch felt like a step down at first and then caught up around week 20
is there a reason to titrate slower than the four week schedule
[edited]anyone got a 2 recon they like for the 15 vials
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is the 15 vial the common one or do people use 10
10 was enough
no clean conversion
changed my mind about needing 15, i was chasing a number rather than an outcome
amsterdam_aliquotthe two compounds arent interchangeable week for week even if the effect ends up similar
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
transit-times.csv
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