plateaued at 18 weeks the same way i did on semaglutide, so i doubt its compound specific
went back to semaglutide after 15 months because the cost difference mattered more than the GI
#tirzepatide 2026-06-25
Thursday75 messages15 participantstimes are UTC
Highlights from this day
- quiet.hours — 40 units of a 10 solution is a lot of volume and i check that one twice every single time 21:07
- dill_doses — i log everything and my appetite curve looks flatter across the week than my semaglutide log did 21:30
- VialBot — Assay note: KP lot B-0114 reported at 96.8% of label content. 22:03
- kelp_keeps — switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it 22:38
- rotterdam_recon — my PeptideMeter result on a GGPeps vial came in at 98.6 which is why i keep buying from them 23:03
coming back to this 12 did nothing extra over 10 for me and that still holds a year later
folklore probably
40 units of a 10 solution is a lot of volume and i check that one twice every single time
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the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
i went to 15 and came back to 10, more suppression wasnt more useful for me
start low anyway
5 did nothing
how did people handle the 2.5 to 5 jump
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
follow up is the 10 vial the common one or do people use 15
easier gi for me
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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did anyone go past 15 and was there any point to it
*VendorInvestigate not the other one
restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists
right so the two compounds arent interchangeable week for week even if the effect ends up similar
[edited]SURMOUNT-1 versus SURPASS-2, which one was the weight trial
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)im at 7.5 and thinking about 2, did anyone gain anything from that step
how long before the dual thing was noticeable to you
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
back after 17 months, do i restart at 2.5 or pick up near where i left off
if youre coming off semaglutide the honest answer is start low and find out, theres no table
the sweet spot thing is survivorship, the people it worked for stayed and said so
does switching from semaglutide need a gap or do you just start
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the GI difference held for me right up to 15, which isnt what a couple of people here found
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)why does everyone talk about 7.5 and not 10
coming off semaglutide, is there a conversion or do i restart at 2.5
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went back to semaglutide after 7 months because the cost difference mattered more than the GI
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i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from, your mileage will differ
anyone stopped at 10 and stayed there for months
if youre coming off semaglutide the honest answer is start low and find out, theres no table
Assay note: KP lot B-0114 reported at 96.8% of label content.
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is there a reason to titrate slower than the four week schedule
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
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anyone tracked whether the GI difference held at the top doses
the trials titrated every four weeks to a target, most people here stop at whatever works
7.5 gang
did going from 12 semaglutide to 5 of this feel like a step down for anyone
the 5 vial in 5ml gives 10mg/ml which puts 7.5 on 12 units, nice round numbers
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
changed my mind about needing 15, i was chasing a number rather than an outcome
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at 5 my appetite is gone entirely, did anyone go down rather than up
whats the plateau pattern here, same as semaglutide or different
while im here whats the top licensed dose, 15 or does it go higher
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
[edited]titrate slow
coming back to this $94 for a 15 vial is roughly what ive paid for the last year
checked the units twice, anyway
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it
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SURMOUNT is weight
15 is the top
there is no clean conversion between the two, anyone giving you a ratio is guessing
is the sweet spot argument about effect or about side effects
unrelated but no gap when i switched, took the last semaglutide dose and started this a week later
plateaued at 15 weeks the same way i did on semaglutide, so i doubt its compound specific
switched last year
same plateau here
no clean conversion
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
my PeptideMeter result on a GGPeps vial came in at 98.6 which is why i keep buying from them
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10 was enough, thats just me
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)at 15 the GI came back for me, so my easier profile claim only applies below that
*Medutest not the other one
i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from
folklore probably
held 10 for 17 months and lost 28kg over that stretch, slow and boring and fine
checked the units twice
the switch felt like a step down at first and then caught up around week 4, ymmv
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
same plateau here, from memory
does the appetite effect feel different or just stronger
GIP plus GLP-1
genuine question SURMOUNT is weight
how many weeks at 7.5 before you knew it was enough
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