restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists
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#tirzepatide 2026-05-23
Saturday60 messages15 participantstimes are UTC
Highlights from this day
- bea_reconstitutes — restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists 14:56
- bac_water_bill — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 15:01
- thistle_tests — $38 for a 5 vial is roughly what ive paid for the last year, ymmv the trials titrated every four weeks to a target, most people here stop at whatever works 16:09
- snac_and_water — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 17:15
- triple_ag_tom — is 7.5 really the sweet spot or is that just channel folklore 18:05
how long before the dual thing was noticeable to you
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT is weight
went back to semaglutide after 19 months because the cost difference mattered more than the GI
[edited]i log everything and my appetite curve looks flatter across the week than my semaglutide log did, someone check my working
no clean conversion
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switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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while im here the 5 vial in 5ml gives 4mg/ml which puts 1 on 5 units, nice round numbers
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is the sweet spot argument about effect or about side effects
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did anyone go past 15 and was there any point to it
switched last year
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
$38 for a 5 vial is roughly what ive paid for the last year, ymmv
the trials titrated every four weeks to a target, most people here stop at whatever works
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did anyone find the GI easier than semaglutide at an equivalent effect
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i went to 15 and came back to 10, more suppression wasnt more useful for me
bac_water_billSURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix…
anyone stopped at 10 and stayed there for months
the switch felt like a step down at first and then caught up around week 10
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the trials titrated every four weeks to a target, most people here stop at whatever works
folklore probably
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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5 did nothing
10 was enough
7.5 gang
the two compounds arent interchangeable week for week even if the effect ends up similar, ill dig out the number
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whats the plateau pattern here, same as semaglutide or different
changed my mind about needing 15, i was chasing a number rather than an outcome
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the sweet spot thing is survivorship, the people it worked for stayed and said so
the 5 vial in 5ml gives 2.5mg/ml which puts 7.5 on 50 units, nice round numbers
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my Janoshik result on a GL Biochem vial came in at 97.4 which is why i keep buying from them, not advice obviously
held 10 for 14 months and lost 24kg over that stretch, slow and boring and fine
[edited]at 0.25 my appetite is gone entirely, did anyone go down rather than up
GIP plus GLP-1
is 7.5 really the sweet spot or is that just channel folklore
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there is no clean conversion between the two, anyone giving you a ratio is guessing
40 units of a 4 solution is a lot of volume and i check that one twice every single time
titrate slow
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start low anyway
no gap when i switched, took the last semaglutide dose and started this a week later
while im here 12 did nothing extra over 10 for me and that still holds a year later
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*that should say weekly
coming off semaglutide, is there a conversion or do i restart at 2.5
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checked the units twice
7.5 gang, your mileage will differ
update on the earlier thing is SURMOUNT-OSA the sleep apnoea one
changed my mind about needing 15, i was chasing a number rather than an outcome
sorry to jump in how did people handle the 2.5 to 5 jump
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same plateau here
the GI difference held for me right up to 15, which isnt what a couple of people here found
at 15 the GI came back for me, so my easier profile claim only applies below that
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, happy to be corrected
the sweet spot argument is really about effect per side effect, not a magic number
5 was where i first noticed it properly, 2.5 did almost nothing for me
at 15 the GI came back for me, so my easier profile claim only applies below that
how many weeks at 7.5 before you knew it was enough
*week 14 not week 6
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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15 is the top
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