#tirzepatide 2026-05-22

Friday17 messages4 participantstimes are UTC

Highlights from this day

point_two_five — at 15 the GI came back for me, so my easier profile claim only applies below that, take that with a pinch of salt 18:22
point_two_five — for the archive switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it 18:33
dana_titrates — went back to semaglutide after 16 months because the cost difference mattered more than the GI 18:45
ari_arrives — ok so restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists 19:08

the trials titrated every four weeks to a target, most people here stop at whatever works

5 did nothing

❤️1👍1

genuine question did going from 15 semaglutide to 5 of this feel like a step down for anyone

at 15 the GI came back for me, so my easier profile claim only applies below that, take that with a pinch of salt

12 did nothing extra over 10 for me and that still holds a year later

for the archive switched from 1.7 semaglutide and started at 2.5, took the slow route, never regretted it

the two compounds arent interchangeable week for week even if the effect ends up similar

i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from

the 2.5 to 5 step was the roughest one for me and everything after was easier

the 10 vial in 2.5ml gives 10mg/ml which puts 0.5 on 50 units, nice round numbers

went back to semaglutide after 16 months because the cost difference mattered more than the GI

i argued the sweet spot was nonsense and then spent 3 months at 7.5 not needing more

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific

SURMOUNT-1 versus SURPASS-2, which one was the weight trial

ok so restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists

titrate slow