#tirzepatide 2026-02-04

Wednesday14 messages3 participantstimes are UTC

Highlights from this day

amsterdam_aliquot — plateaued at 11 weeks the same way i did on semaglutide, so i doubt its compound specific 04:49
split_the_cost — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 05:43
iris_imports — i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from, ask me again in a month 06:18
split_the_cost — there is no clean conversion between the two, anyone giving you a ratio is guessing 06:22

plateaued at 11 weeks the same way i did on semaglutide, so i doubt its compound specific

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

at 15 the GI came back for me, so my easier profile claim only applies below that

while im here dual agonist, GIP as well as GLP-1, thats the whole difference in one line

titrate slow

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

whats the top licensed dose, 15 or does it go higher

does the GIP arm actually explain the easier nausea or is that hand waving

SURMOUNT is weight

i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from, ask me again in a month

anyone tracked whether the GI difference held at the top doses

[edited]

there is no clean conversion between the two, anyone giving you a ratio is guessing

🎉8👀15

7.5 gang

coming off semaglutide, is there a conversion or do i restart at 2.5

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted