is the sweet spot argument about effect or about side effects
#tirzepatide 2026-04-18
Saturday74 messages11 participantstimes are UTC
Highlights from this day
- vienna_vial — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, anyway 14:03
- snac_and_water — changed my mind about needing 15, i was chasing a number rather than an outcome, your mileage will differ 14:30
- slow.taper — restarted at 2.5 after 16 months off and the first two doses reminded me why titration exists 14:45
- point_two_five — 12 did nothing extra over 10 for me and that still holds a year later, not advice obviously 15:28
- vienna_vial — held 10 for 16 months and lost 41kg over that stretch, slow and boring and fine 15:37
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, anyway
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my VendorInvestigate result on a CPC vial came in at 98.6 which is why i keep buying from them
ok so is the 5 vial the common one or do people use 20
plateaued at 29 weeks the same way i did on semaglutide, so i doubt its compound specific
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start low anyway
the two compounds arent interchangeable week for week even if the effect ends up similar, happy to be corrected
the sweet spot argument is really about effect per side effect, not a magic number
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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changed my mind about needing 15, i was chasing a number rather than an outcome, your mileage will differ
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7.5 gang
anyone tracked whether the GI difference held at the top doses
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
how long before the dual thing was noticeable to you
snac_and_waterchanged my mind about needing 15, i was chasing a number rather than an outcome, your…
restarted at 2.5 after 16 months off and the first two doses reminded me why titration exists
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no clean conversion
back after 15 months, do i restart at 2.5 or pick up near where i left off
did anybody switch back to semaglutide after trying this
at 15 the GI came back for me, so my easier profile claim only applies below that
quick one SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
the GI difference held for me right up to 15, which isnt what a couple of people here found
12 did nothing extra over 10 for me and that still holds a year later, not advice obviously
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held 10 for 16 months and lost 41kg over that stretch, slow and boring and fine
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the 40 vial in 3ml gives 8mg/ml which puts 15 on 10 units, nice round numbers
titrate slow
ok so whats the plateau pattern here, same as semaglutide or different
there is no clean conversion between the two, anyone giving you a ratio is guessing
does switching from semaglutide need a gap or do you just start
no gap when i switched, took the last semaglutide dose and started this a week later
folklore probably
plateaued at 18 weeks the same way i did on semaglutide, so i doubt its compound specific
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
5 was where i first noticed it properly, 2.5 did almost nothing for me
SURMOUNT is weight
[edited]does the GIP arm actually explain the easier nausea or is that hand waving
[edited]5 did nothing
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the sweet spot thing is survivorship, the people it worked for stayed and said so
slightly off topic but at 15 the GI came back for me, so my easier profile claim only applies below that
start low anyway
the switch felt like a step down at first and then caught up around week 28
[edited]15 is the top
plateaued at 11 weeks the same way i did on semaglutide, so i doubt its compound specific
10 was enough
for the archive if youre coming off semaglutide the honest answer is start low and find out, theres no table
went back to semaglutide after 9 months because the cost difference mattered more than the GI
GIP plus GLP-1
for the archive $55 for a 40 vial is roughly what ive paid for the last year
did going from 2 semaglutide to 5 of this feel like a step down for anyone
40 units of a 8 solution is a lot of volume and i check that one twice every single time
coming off semaglutide, is there a conversion or do i restart at 2.5
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, from memory
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
easier gi for me, thats one data point
titrate slow
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i argued the sweet spot was nonsense and then spent 2 months at 7.5 not needing more, happy to be corrected
anyone stopped at 10 and stayed there for months
i went to 15 and came back to 10, more suppression wasnt more useful for me
same plateau here
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7.5 gang
at 15 the GI came back for me, so my easier profile claim only applies below that
two_lifts_a_weekslightly off topic but at 15 the GI came back for me, so my easier profile claim only…
did anyone go past 15 and was there any point to it
does the appetite effect feel different or just stronger
quick one how did people handle the 2.5 to 5 jump
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)7.5 gang
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at 1 my appetite is gone entirely, did anyone go down rather than up
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anyone got a 10 recon they like for the 5 vials
no gap when i switched, took the last semaglutide dose and started this a week later
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
quick one im at 7.5 and thinking about 2, did anyone gain anything from that step
folklore probably
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SURMOUNT is weight, thats just me
the 2.5 to 5 step was the roughest one for me and everything after was easier
is there a reason to titrate slower than the four week schedule
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