SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
#tirzepatide 2026-05-16
Saturday52 messages12 participantstimes are UTC
Highlights from this day
- bpc_sceptic — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 19:45
- maintenance_mo — if youre coming off semaglutide the honest answer is start low and find out, theres no table 22:07
- maintenance_mo — €185 for a 30 vial is roughly what ive paid for the last year, ill dig out the number 22:09
- related_subs — the trials titrated every four weeks to a target, most people here stop at whatever works 22:16
changed my mind about needing 15, i was chasing a number rather than an outcome
how long before the dual thing was noticeable to you
5 was where i first noticed it properly, 2.5 did almost nothing for me
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checked the units twice
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
15 is the top
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the GI difference held for me right up to 15, which isnt what a couple of people here found, ymmv
no clean conversion
there is no clean conversion between the two, anyone giving you a ratio is guessing
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restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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at 15 the GI came back for me, so my easier profile claim only applies below that
i went to 15 and came back to 10, more suppression wasnt more useful for me
is SURMOUNT-OSA the sleep apnoea one
the switch felt like a step down at first and then caught up around week 29
5 did nothing
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held 10 for 5 months and lost 12kg over that stretch, slow and boring and fine
easier gi for me
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, i have it written down somewhere
did anyone find the GI easier than semaglutide at an equivalent effect
quick one 40 units of a 4 solution is a lot of volume and i check that one twice every single time
the two compounds arent interchangeable week for week even if the effect ends up similar
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
switched last year
did anyone go past 15 and was there any point to it
switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it
my PeptideMeter result on a TFC vial came in at 99 which is why i keep buying from them
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the sweet spot argument is really about effect per side effect, not a magic number, ask me again in a month
went back to semaglutide after 7 months because the cost difference mattered more than the GI
at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
[edited]*week 18 not week 5
i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from
[edited]12 did nothing extra over 10 for me and that still holds a year later, happy to be corrected
plateaued at 22 weeks the same way i did on semaglutide, so i doubt its compound specific
no gap when i switched, took the last semaglutide dose and started this a week later
5 was where i first noticed it properly, 2.5 did almost nothing for me
how many weeks at 7.5 before you knew it was enough
titrate slow
the 2.5 to 5 step was the roughest one for me and everything after was easier
start low anyway
folklore probably
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GIP plus GLP-1
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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€185 for a 30 vial is roughly what ive paid for the last year, ill dig out the number
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)7.5 gang
sorry to jump in im at 2.5 and thinking about 1.7, did anyone gain anything from that step
whats the plateau pattern here, same as semaglutide or different
the 15 vial in 1.5ml gives 2mg/ml which puts 5 on 15 units, nice round numbers, we shall see
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10 was enough
the trials titrated every four weeks to a target, most people here stop at whatever works
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