#tirzepatide 2025-10-07

Tuesday14 messages4 participantstimes are UTC

Highlights from this day

gradient_greg — the trials titrated every four weeks to a target, most people here stop at whatever works 19:00
gradient_greg — did anyone go past 15 and was there any point to it 19:11
chlorhex — held 10 for 12 months and lost 36kg over that stretch, slow and boring and fine 19:45
chlorhex — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 20:41

changed my mind about needing 15, i was chasing a number rather than an outcome

the sweet spot argument is really about effect per side effect, not a magic number, n of 1 obviously

quick one plateaued at 22 weeks the same way i did on semaglutide, so i doubt its compound specific

the trials titrated every four weeks to a target, most people here stop at whatever works

👀2🧊7

does the appetite effect feel different or just stronger

did anyone go past 15 and was there any point to it

💀1🎉1

at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win

held 10 for 12 months and lost 36kg over that stretch, slow and boring and fine

👍9🧊1💀4

checked the units twice

the 2 vial in 5ml gives 10mg/ml which puts 0.5 on 30 units, nice round numbers

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

🎉4⚠️3📉4

at 15 the GI came back for me, so my easier profile claim only applies below that

switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it

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