Compounds
#retatrutide
Retatrutide. Triple agonist. Research use only. No long-term safety data.
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465day logs
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GIP/GLP-1/glucagon triple agonism. The Phase 2 result (NEJM 2023), the TRIUMPH programme, what the glucagon arm appears to do to resting heart rate, and the room’s consistent position: low and slow, log your heart rate, and be honest that there is no long-term safety data.
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There is no long-term safety data on retatrutide. None. Anyone who tells you otherwise is confusing a Phase 2 result with a safety record.
If you are running this, log resting heart rate and blood pressure daily from before you start. The glucagon arm is not free and the room wants the data.
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Direct manufacturerGL Biochem (Shanghai) Ltd. — the synthesis houseFounded 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. A great deal of what gets sent for testing was made here first. Custom synthesis quoted to small orders.Browse GL Biochem →Most recent logs
2026-06-30did the phase 2 result actually come in higher than the tirzepatide numbers16 msgs · 4 people2026-06-29low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, thats just me54 msgs · 10 people2026-06-27TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule45 msgs · 12 people2026-06-26low and slow17 msgs · 5 people2026-06-25no long term data29 msgs · 9 people2026-06-24watching my heart rate18 msgs · 3 people2026-06-23TRIUMPH is phase 320 msgs · 4 people2026-06-22research use only35 msgs · 10 people2026-06-21phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan58 msgs · 12 people2026-06-18how do people square the research use only framing with logging their own use GI was about the same as tirzepatide for…24 msgs · 5 people2026-06-17held at 1 for 17 months and it never plateaued for me, which i cant explain, n of 1 obviously62 msgs · 14 people2026-06-16held mine ages35 msgs · 7 people2026-06-15is there any long term safety data at all or is it phase 2 and hope48 msgs · 8 people2026-06-14genuine question triple agonist meaning GLP-1, GIP and glucagon, have i got that right26 msgs · 6 people2026-06-13watching my heart rate21 msgs · 5 people2026-06-12while im here how do people square the research use only framing with logging their own use16 msgs · 4 people2026-06-11how long before people saw the first change at 524 msgs · 4 people2026-06-10did anyone come off because of the heart rate30 msgs · 8 people2026-06-09settled by month three15 msgs · 5 people2026-06-07low and slow67 msgs · 14 people2026-06-06quick one im at 2.4 and the appetite effect is stronger than i expected, normal43 msgs · 8 people2026-06-05stepping in 0.25 increments instead of doubling is the only thing i would change if i started again, i could be wrong45 msgs · 9 people2026-06-04anyone logging resting heart rate on this54 msgs · 12 people2026-06-03my resting rate went up 9 bpm in the first month and came back most of the way by month 825 msgs · 7 people2026-06-02the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial24 msgs · 5 people2026-06-01the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial25 msgs · 7 people2026-05-31settled by month three19 msgs · 5 people2026-05-30the heart rate thing is real enough that i mention it whenever someone asks about starting57 msgs · 9 people2026-05-29low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom42 msgs · 8 people2026-05-28logging rhr daily19 msgs · 5 people
Threads spun off from this channel
i said 8 months ago that my heart rate2026-06-11 · 8 msgsGI was about the same as tirzepatide for me2026-06-07 · 7 msgscoming back to this people insist on small steps2026-06-05 · 12 msgsis the glucagon arm what people mean by the2026-05-30 · 13 msgsanyone logging resting heart rate on this2026-05-25 · 7 msgspeople insist on small steps because the side effects2026-05-19 · 17 msgsdid the phase 2 plateau or was it still2026-05-16 · 8 msgshow do people square the research use only framing2026-05-10 · 16 msgsblood pressure stayed flat for me while heart rate2026-04-11 · 6 msgssorry to jump in reconstituted the 15 vial to2026-03-31 · 5 msgsmy resting rate went up 8 bpm in the2026-03-28 · 7 msgsheld at 2.4 for 1 months and it never2026-03-26 · 11 msgsreconstituted the 2 vial to 8mg/ml specifically so i2026-02-06 · 10 msgsheld at 0.5 for 16 months and it never2026-01-29 · 9 msgsthe half life supports weekly dosing and thats what2026-01-18 · 8 msgsbuying this is a completely different risk conversation from2026-01-12 · 11 msgsMedutest not the other one2025-11-28 · 14 msgsdoes the glucagon arm explain the heart rate or2025-11-08 · 15 msgsresearch use only is on every vial and i2025-10-27 · 14 msgscoming back to this how slow is low and2025-09-15 · 15 msgswhy does everyone insist on smaller steps here than2025-08-29 · 15 msgsanyone logging resting heart rate on this2025-08-23 · 6 msgsthe phase 2 weight result was larger than what2025-08-13 · 17 msgsanyone stayed at 0.5 for months rather than climbing2025-08-08 · 6 msgs