switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it
#tirzepatide 2025-12-10
Wednesday18 messages6 participantstimes are UTC
Highlights from this day
restarted at 2.5 after 1 months off and the first two doses reminded me why titration exists
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)Reminder set. I will post here in 3 days.
quick one if youre coming off semaglutide the honest answer is start low and find out, theres no table
switched last year
5 was where i first noticed it properly, 2.5 did almost nothing for me
Batch lookup SG-1177: 4 independent reports on file, earliest 2025-05-07.
does the GIP arm actually explain the easier nausea or is that hand waving
there is no clean conversion between the two, anyone giving you a ratio is guessing
no clean conversion
unrelated but licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
£240 for a 20 vial is roughly what ive paid for the last year
is SURMOUNT-OSA the sleep apnoea one
15 is the top
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how did people handle the 2.5 to 5 jump
the GI difference held for me right up to 15, which isnt what a couple of people here found
the sweet spot thing is survivorship, the people it worked for stayed and said so
5 did nothing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |