did anybody switch back to semaglutide after trying this
[edited]#tirzepatide 2026-06-19
Friday49 messages11 participantstimes are UTC
Highlights from this day
- ms_ms_mira — my Janoshik result on a QSC vial came in at 99.2 which is why i keep buying from them 18:15
- gip_glp_gil — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 18:31
- ms_ms_mira — i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from 19:33
- peak_split — coming back to this plateaued at 28 weeks the same way i did on semaglutide, so i doubt its compound specific 21:35
- retention_time — the trials titrated every four weeks to a target, most people here stop at whatever works 21:45
while im here 12 did nothing extra over 10 for me and that still holds a year later
my Janoshik result on a QSC vial came in at 99.2 which is why i keep buying from them
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no clean conversion
unrelated but im at 1 and thinking about 2.5, did anyone gain anything from that step
went back to semaglutide after 12 months because the cost difference mattered more than the GI, n of 1 obviously
fridge-temps.csv
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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right so changed my mind about needing 15, i was chasing a number rather than an outcome
no gap when i switched, took the last semaglutide dose and started this a week later
folklore probably
anyone got a 2 recon they like for the 20 vials
15 is the top
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i went to 15 and came back to 10, more suppression wasnt more useful for me
the GI difference held for me right up to 15, which isnt what a couple of people here found, i think
at 15 the GI came back for me, so my easier profile claim only applies below that
5 did nothing
i sat at 7.5 for 15 months and never needed more, which is where the folklore comes from
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slightly off topic but the switch felt like a step down at first and then caught up around week 30
*PeptideMeter not the other one
while im here the two compounds arent interchangeable week for week even if the effect ends up similar, someone check my working
5 was where i first noticed it properly, 2.5 did almost nothing for me
whats the top licensed dose, 15 or does it go higher
restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists
held 10 for 10 months and lost 15kg over that stretch, slow and boring and fine, i have it written down somewhere
there is no clean conversion between the two, anyone giving you a ratio is guessing
the sweet spot argument is really about effect per side effect, not a magic number, take that with a pinch of salt
i argued the sweet spot was nonsense and then spent 15 months at 7.5 not needing more
at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
unrelated but the 30 vial in 1.5ml gives 8mg/ml which puts 1 on 20 units, nice round numbers
switched last year
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
start low anyway
medutest-report-e-2205.pdf
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did anyone find the GI easier than semaglutide at an equivalent effect
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
why does everyone talk about 7.5 and not 10
easier gi for me
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
how did people handle the 2.5 to 5 jump
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
7.5 gang
$94 for a 2 vial is roughly what ive paid for the last year
Purity check: no report on file for lot SG-1177. Nothing logged either way.
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
SURMOUNT is weight
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if youre coming off semaglutide the honest answer is start low and find out, theres no table, i have it written down somewhere
the sweet spot thing is survivorship, the people it worked for stayed and said so
coming back to this plateaued at 28 weeks the same way i did on semaglutide, so i doubt its compound specific
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the trials titrated every four weeks to a target, most people here stop at whatever works
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)dual agonist, GIP as well as GLP-1, thats the whole difference in one line
same plateau here
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