changed my mind about needing 15, i was chasing a number rather than an outcome
#tirzepatide 2026-03-24
Tuesday31 messages8 participantstimes are UTC
Highlights from this day
- mg_per_ml — slightly off topic but the trials titrated every four weeks to a target, most people here stop at whatever works 16:30
- group_buy_gwen — does the appetite effect feel different or just stronger 16:31
- group_buy_gwen — my Janoshik result on a FGP vial came in at 98.6 which is why i keep buying from them 18:08
- apnoea_down_two — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 18:11
whats the top licensed dose, 15 or does it go higher
Reminder for mg_per_ml: dose day is today. Set 2 days ago.
no gap when i switched, took the last semaglutide dose and started this a week later
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
back after 6 months, do i restart at 2.5 or pick up near where i left off
slightly off topic but the trials titrated every four weeks to a target, most people here stop at whatever works
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
does the appetite effect feel different or just stronger
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there is no clean conversion between the two, anyone giving you a ratio is guessing
checked the units twice
the sweet spot thing is survivorship, the people it worked for stayed and said so, thats just me
the 2.5 to 5 step was the roughest one for me and everything after was easier, take that with a pinch of salt
went back to semaglutide after 24 months because the cost difference mattered more than the GI
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5 did nothing
if youre coming off semaglutide the honest answer is start low and find out, theres no table
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
folklore probably
while im here the switch felt like a step down at first and then caught up around week 32
titrate slow
my Janoshik result on a FGP vial came in at 98.6 which is why i keep buying from them
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plateaued at 18 weeks the same way i did on semaglutide, so i doubt its compound specific
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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is 7.5 really the sweet spot or is that just channel folklore
restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
at 15 the GI came back for me, so my easier profile claim only applies below that
the 2 vial in 2.5ml gives 10mg/ml which puts 2.4 on 12 units, nice round numbers
the two compounds arent interchangeable week for week even if the effect ends up similar
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did anyone find the GI easier than semaglutide at an equivalent effect
15 is the top
10 was enough
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for the archive the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact