40 units of a 2 solution is a lot of volume and i check that one twice every single time
#tirzepatide 2026-05-08
Friday59 messages10 participantstimes are UTC
Highlights from this day
- blind_submit — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 17:55
- hair_month_four — switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it 18:20
- hair_month_four — $240 for a 5 vial is roughly what ive paid for the last year 18:28
- mhra_unlicensed — is the 10 vial the common one or do people use 2 19:57
- noct.titrate — my Janoshik result on a GGPeps vial came in at 96.8 which is why i keep buying from them 20:34
the two compounds arent interchangeable week for week even if the effect ends up similar
no clean conversion
anyone stopped at 10 and stayed there for months
15 is the top
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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how many weeks at 7.5 before you knew it was enough
right so i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
is the sweet spot argument about effect or about side effects
is SURMOUNT-OSA the sleep apnoea one
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
there is no clean conversion between the two, anyone giving you a ratio is guessing
same plateau here
restarted at 2.5 after 26 months off and the first two doses reminded me why titration exists
$240 for a 5 vial is roughly what ive paid for the last year
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
SURMOUNT is weight
changed my mind about needing 15, i was chasing a number rather than an outcome, ymmv
5 was where i first noticed it properly, 2.5 did almost nothing for me
did going from 10 semaglutide to 5 of this feel like a step down for anyone
the 40 vial in 3ml gives 2.5mg/ml which puts 10 on 8 units, nice round numbers
40 units of a 2 solution is a lot of volume and i check that one twice every single time
folklore probably
follow up back after 25 months, do i restart at 2.5 or pick up near where i left off
im at 12 and thinking about 2.4, did anyone gain anything from that step
start low anyway
the switch felt like a step down at first and then caught up around week 34
how did people handle the 2.5 to 5 jump
no gap when i switched, took the last semaglutide dose and started this a week later
restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
plateaued at 16 weeks the same way i did on semaglutide, so i doubt its compound specific
at 2.5 my appetite is gone entirely, did anyone go down rather than up
i went to 15 and came back to 10, more suppression wasnt more useful for me, not advice obviously
5 did nothing
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is the 10 vial the common one or do people use 2
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)went back to semaglutide after 1 months because the cost difference mattered more than the GI
12 did nothing extra over 10 for me and that still holds a year later
changed my mind about needing 15, i was chasing a number rather than an outcome
easier gi for me
did anybody switch back to semaglutide after trying this
quick one held 10 for 10 months and lost 3kg over that stretch, slow and boring and fine
my Janoshik result on a GGPeps vial came in at 96.8 which is why i keep buying from them
whats the top licensed dose, 15 or does it go higher
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quick one does the GIP arm actually explain the easier nausea or is that hand waving
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checked the units twice
did anyone find the GI easier than semaglutide at an equivalent effect
switched last year
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GIP plus GLP-1
titrate slow
while im here the 2.5 to 5 step was the roughest one for me and everything after was easier
10 was enough
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the trials titrated every four weeks to a target, most people here stop at whatever works, someone check my working
at 15 the GI came back for me, so my easier profile claim only applies below that, n of 1 obviously
there is no clean conversion between the two, anyone giving you a ratio is guessing
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
7.5 gang
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