the switch felt like a step down at first and then caught up around week 33
#tirzepatide 2026-01-20
Tuesday28 messages7 participantstimes are UTC
Highlights from this day
- sharps_bin_sid — did going from 2.4 semaglutide to 5 of this feel like a step down for anyone 15:36
- luerlok — coming back to this SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 16:44
- evidence_or_not — the trials titrated every four weeks to a target, most people here stop at whatever works, ymmv 16:47
- ferritin_fay — no gap when i switched, took the last semaglutide dose and started this a week later 18:44
12 did nothing extra over 10 for me and that still holds a year later
5 did nothing
coming back to this 40 units of a 2 solution is a lot of volume and i check that one twice every single time
start low anyway
unrelated but whats the top licensed dose, 15 or does it go higher
[edited]licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the two compounds arent interchangeable week for week even if the effect ends up similar
i went to 15 and came back to 10, more suppression wasnt more useful for me
titrate slow
🧊8🙏2
no clean conversion
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
🎉11🔥1👀4
10 was enough
checked the units twice
coming back to this SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the trials titrated every four weeks to a target, most people here stop at whatever works, ymmv
⚠️1
held 10 for 14 months and lost 21kg over that stretch, slow and boring and fine, someone check my working
the GI difference held for me right up to 15, which isnt what a couple of people here found
did anyone find the GI easier than semaglutide at an equivalent effect
does the GIP arm actually explain the easier nausea or is that hand waving
if youre coming off semaglutide the honest answer is start low and find out, theres no table
no gap when i switched, took the last semaglutide dose and started this a week later
✅7👀9
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
whats the plateau pattern here, same as semaglutide or different
restarted at 2.5 after 13 months off and the first two doses reminded me why titration exists
same plateau here
⚠️6🧪16
the sweet spot argument is really about effect per side effect, not a magic number