is SURMOUNT-OSA the sleep apnoea one
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
#tirzepatide 2026-01-08
Thursday29 messages8 participantstimes are UTC
Highlights from this day
- hair_month_four — did anyone find the GI easier than semaglutide at an equivalent effect 16:57
- hair_month_four — unrelated but went back to semaglutide after 10 months because the cost difference mattered more than the GI i argued the sweet spot was nonsense and then spent 20… 17:56
- lena_lots — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 19:03
- acetate_ash — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ymmv 19:10
- VialBot — Inter-lab diff for lot B-0114: 98.1% vs 98.6%. Within expected range. 19:16
why does everyone talk about 7.5 and not 10
did anyone find the GI easier than semaglutide at an equivalent effect
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the trials titrated every four weeks to a target, most people here stop at whatever works
5 did nothing
slightly off topic but i argued the sweet spot was nonsense and then spent 8 months at 7.5 not needing more
[edited]10 was enough
GIP plus GLP-1
❤️10
easier gi for me
at 15 the GI came back for me, so my easier profile claim only applies below that
the two compounds arent interchangeable week for week even if the effect ends up similar, take that with a pinch of salt
*that should say weekly
7.5 gang
switched last year
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)👍5
5 was where i first noticed it properly, 2.5 did almost nothing for me, your mileage will differ
checked the units twice
unrelated but went back to semaglutide after 10 months because the cost difference mattered more than the GI
i argued the sweet spot was nonsense and then spent 20 months at 7.5 not needing more
ok so is the sweet spot argument about effect or about side effects
the 10 vial in 1ml gives 2mg/ml which puts 1 on 12 units, nice round numbers
same plateau here
coming back to this 12 did nothing extra over 10 for me and that still holds a year later
the GI difference held for me right up to 15, which isnt what a couple of people here found
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restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists
no clean conversion
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, ymmv
fridge-temps.csv
820 rows · not retained in the public archive
quick one how did people handle the 2.5 to 5 jump
Inter-lab diff for lot B-0114: 98.1% vs 98.6%. Within expected range.