for the archive coming off semaglutide, is there a conversion or do i restart at 2.5
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#tirzepatide 2025-11-05
Wednesday62 messages10 participantstimes are UTC
Highlights from this day
- never_for_sale — for the archive coming off semaglutide, is there a conversion or do i restart at 2.5 20:17
- rotterdam_recon — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 21:07
- subq_sy — went back to semaglutide after 18 months because the cost difference mattered more than the GI, thats just me 21:44
my Janoshik result on a QYB vial came in at 97.4 which is why i keep buying from them, happy to be corrected
did anybody switch back to semaglutide after trying this
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i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more
changed my mind about needing 15, i was chasing a number rather than an outcome
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same plateau here
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10 was enough
checked the units twice
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the sweet spot thing is survivorship, the people it worked for stayed and said so
there is no clean conversion between the two, anyone giving you a ratio is guessing
back after 25 months, do i restart at 2.5 or pick up near where i left off
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does the appetite effect feel different or just stronger
12 did nothing extra over 10 for me and that still holds a year later
the GI difference held for me right up to 15, which isnt what a couple of people here found
7.5 gang
right so is the sweet spot argument about effect or about side effects
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€38 for a 40 vial is roughly what ive paid for the last year
right so did going from 2.5 semaglutide to 5 of this feel like a step down for anyone
the 40 vial in 1ml gives 10mg/ml which puts 0.25 on 30 units, nice round numbers
the trials titrated every four weeks to a target, most people here stop at whatever works
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
5 was where i first noticed it properly, 2.5 did almost nothing for me
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whats the plateau pattern here, same as semaglutide or different
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
start low anyway
why does everyone talk about 7.5 and not 10
no clean conversion
slightly off topic but anyone got a 2.5 recon they like for the 10 vials
titrate slow
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folklore probably
plateaued at 17 weeks the same way i did on semaglutide, so i doubt its compound specific, we shall see
how many weeks at 7.5 before you knew it was enough
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
[edited]im at 12 and thinking about 1, did anyone gain anything from that step
[edited]went back to semaglutide after 18 months because the cost difference mattered more than the GI, thats just me
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the sweet spot argument is really about effect per side effect, not a magic number
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists, i think
how long before the dual thing was noticeable to you
at 15 the GI came back for me, so my easier profile claim only applies below that
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SURMOUNT is weight
whats the top licensed dose, 15 or does it go higher
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GIP plus GLP-1
switched last year
peptidemeter-summary-a-2418.pdf
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is 7.5 really the sweet spot or is that just channel folklore
40 units of a 8 solution is a lot of volume and i check that one twice every single time
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the two compounds arent interchangeable week for week even if the effect ends up similar
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i went to 15 and came back to 10, more suppression wasnt more useful for me, not advice obviously
anyone stopped at 10 and stayed there for months
is SURMOUNT-OSA the sleep apnoea one
is the 20 vial the common one or do people use 5
folklore probably
easier gi for me
held 10 for 9 months and lost 48kg over that stretch, slow and boring and fine
did anyone go past 15 and was there any point to it
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
no gap when i switched, took the last semaglutide dose and started this a week later, for what its worth
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
does switching from semaglutide need a gap or do you just start
ok so dual agonist, GIP as well as GLP-1, thats the whole difference in one line