#tirzepatide 2026-06-14

Sunday79 messages14 participantstimes are UTC

Highlights from this day

VialBot — Assay note: BCH lot D-0718 reported at 99.4% of label content. 18:27
mg_per_ml — is SURMOUNT-OSA the sleep apnoea one 18:52
mg_per_ml — at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win, from memory 19:00

net_peptide 17:30

no gap when i switched, took the last semaglutide dose and started this a week later

SURMOUNT is weight

slightly off topic but does switching from semaglutide need a gap or do you just start

how did people handle the 2.5 to 5 jump

👀1📉6

a1c_lag 17:43

7.5 gang

sorry to jump in im at 0.5 and thinking about 5, did anyone gain anything from that step

bea_reconstitutes 17:53

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists

net_peptide 17:59

i argued the sweet spot was nonsense and then spent 12 months at 7.5 not needing more

mag_citrate 18:00

coming back to this held 10 for 12 months and lost 24kg over that stretch, slow and boring and fine

bea_reconstitutes restarted at 2.5 after 22 months off and the first two doses reminded me why titration…

mag_citrate 18:05

does the GIP arm actually explain the easier nausea or is that hand waving

went back to semaglutide after 5 months because the cost difference mattered more than the GI

alt_ast_ali 18:11

plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific, happy to be corrected

mag_citrate 18:16

unrelated but dual agonist, GIP as well as GLP-1, thats the whole difference in one line, someone check my working

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is the 30 vial the common one or do people use 10

the two compounds arent interchangeable week for week even if the effect ends up similar

alt_ast_ali 18:25

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

VialBotbot18:27

Assay note: BCH lot D-0718 reported at 99.4% of label content.

mag_citrate does the GIP arm actually explain the easier nausea or is that hand waving

zed_zeroes_in 18:32

folklore probably

vialkeeperfounder18:37

the 2.5 to 5 step was the roughest one for me and everything after was easier

i log everything and my appetite curve looks flatter across the week than my semaglutide log did

zed_zeroes_in 18:47

did anybody switch back to semaglutide after trying this

is there a reason to titrate slower than the four week schedule

at 15 my appetite is gone entirely, did anyone go down rather than up

12 did nothing extra over 10 for me and that still holds a year later, from memory

mag_citrate does the GIP arm actually explain the easier nausea or is that hand waving

mg_per_ml 18:52

is SURMOUNT-OSA the sleep apnoea one

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

zed_zeroes_in 12 did nothing extra over 10 for me and that still holds a year later, from memory

mg_per_ml 18:57

no clean conversion

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net_peptide slightly off topic but does switching from semaglutide need a gap or do you just start

mg_per_ml 18:58

i went to 15 and came back to 10, more suppression wasnt more useful for me

at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win, from memory

👍5📉12😂17

switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it, take that with a pinch of salt

VialBot Assay note: BCH lot D-0718 reported at 99.4% of label content.

cold_chain_cmdr 19:10

quick one how many weeks at 7.5 before you knew it was enough

nordic_price_nils 19:11

the sweet spot argument is really about effect per side effect, not a magic number

cold_chain_cmdr 19:17

i sat at 7.5 for 13 months and never needed more, which is where the folklore comes from

cold_chain_cmdr 19:23

anyone got a 5 recon they like for the 10 vials

nordic_price_nils 19:25

the sweet spot thing is survivorship, the people it worked for stayed and said so

checked the units twice

vialkeeperfounder19:29

5 was where i first noticed it properly, 2.5 did almost nothing for me, we shall see

cmp_baseline 19:31

€94 for a 20 vial is roughly what ive paid for the last year, ill dig out the number

medutest-report-h-2814.pdf

3 pages · 675 KB · not retained in the public archive

is the sweet spot argument about effect or about side effects

zed_zeroes_in is there a reason to titrate slower than the four week schedule

vialkeeperfounder19:34

the trials titrated every four weeks to a target, most people here stop at whatever works, ill dig out the number

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zed_zeroes_in did anybody switch back to semaglutide after trying this

cold_chain_cmdr 19:35

same plateau here

vialkeeperfounder19:41

licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

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net_peptide 19:47

the 15 vial in 2ml gives 8mg/ml which puts 2 on 5 units, nice round numbers

if youre coming off semaglutide the honest answer is start low and find out, theres no table, anyway

surpass_two 19:51

did anyone go past 15 and was there any point to it

surpass_two 19:58

while im here easier gi for me

at 15 the GI came back for me, so my easier profile claim only applies below that

net_peptide 20:00

start low anyway

[edited]

Cited study

Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)

New England Journal of Medicine · 2021

The head-to-head everyone quotes. Note the semaglutide comparator dose.

net_peptide 20:07

switched last year

while im here coming off semaglutide, is there a conversion or do i restart at 2.5

nordic_price_nils 20:10

titrate slow

a1c_lag 20:11

15 is the top

surpass_two while im here easier gi for me

a1c_lag 20:12

right so the GI difference held for me right up to 15, which isnt what a couple of people here found

🎉3

SURMOUNT-1 versus SURPASS-2, which one was the weight trial

mag_citrate 20:14

GIP plus GLP-1

did anyone find the GI easier than semaglutide at an equivalent effect

for the archive whats the top licensed dose, 15 or does it go higher

a1c_lag 20:17

there is no clean conversion between the two, anyone giving you a ratio is guessing

mag_citrate did anyone find the GI easier than semaglutide at an equivalent effect

nordic_price_nils 20:18

anyone stopped at 10 and stayed there for months

nordic_price_nils 20:29

my Janoshik result on a HJ vial came in at 98.1 which is why i keep buying from them

net_peptide 20:35

the switch felt like a step down at first and then caught up around week 2, from memory

is 7.5 really the sweet spot or is that just channel folklore

coming back to this back after 16 months, do i restart at 2.5 or pick up near where i left off

net_peptide 20:51

10 was enough

nordic_price_nils 20:54

changed my mind about needing 15, i was chasing a number rather than an outcome

plateaued at 5 weeks the same way i did on semaglutide, so i doubt its compound specific

VialBotbot20:58

Recon calculator: 2mg in 3ml = 2mg/ml.

cmp_baseline 21:08

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

area_percentlab21:23

SURMOUNT is weight

mag_citrate 21:24

easier gi for me

area_percentlab21:29

whats the plateau pattern here, same as semaglutide or different

cold_chain_cmdr 21:43

anyone tracked whether the GI difference held at the top doses

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

cold_chain_cmdr 22:07

start low anyway

area_percentlab22:18

does the appetite effect feel different or just stronger

❤️5✅4

mag_citrate 22:43

5 did nothing

nordic_price_nils changed my mind about needing 15, i was chasing a number rather than an outcome

mag_citrate 22:50

12 did nothing extra over 10 for me and that still holds a year later

GIP plus GLP-1

the GI difference held for me right up to 15, which isnt what a couple of people here found