no clean conversion
#tirzepatide 2025-11-09
Sunday39 messages8 participantstimes are UTC
Highlights from this day
- seven_five_sweet — plateaued at 20 weeks the same way i did on semaglutide, so i doubt its compound specific 21:30
- lipase_lore — at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win, i could be wrong 21:38
- no_appetite_nia — the sweet spot argument is really about effect per side effect, not a magic number 21:43
- seven_five_sweet — follow up coming off semaglutide, is there a conversion or do i restart at 2.5 22:48
easier gi for me
switched last year
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
if youre coming off semaglutide the honest answer is start low and find out, theres no table
does the appetite effect feel different or just stronger
went back to semaglutide after 25 months because the cost difference mattered more than the GI
the 2 vial in 2.5ml gives 2.5mg/ml which puts 1.7 on 50 units, nice round numbers
❤️1
10 was enough
checked the units twice
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i argued the sweet spot was nonsense and then spent 4 months at 7.5 not needing more
plateaued at 20 weeks the same way i did on semaglutide, so i doubt its compound specific
✅13🧪1👀3
5 did nothing
15 is the top
at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win, i could be wrong
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
❤️2🎉14💀16
the sweet spot argument is really about effect per side effect, not a magic number
😂8📉8
Inter-lab diff for lot C-4402: 96.8% vs 98.1%. Within expected range.
€55 for a 15 vial is roughly what ive paid for the last year
GIP plus GLP-1
titrate slow
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT is weight
at 1.7 my appetite is gone entirely, did anyone go down rather than up
did anyone find the GI easier than semaglutide at an equivalent effect
did anyone go past 15 and was there any point to it
7.5 gang
how did people handle the 2.5 to 5 jump
folklore probably
is the 40 vial the common one or do people use 2
restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists
follow up coming off semaglutide, is there a conversion or do i restart at 2.5
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i went to 15 and came back to 10, more suppression wasnt more useful for me
On this day 3 years ago this channel logged 16 messages.
the two compounds arent interchangeable week for week even if the effect ends up similar
the sweet spot thing is survivorship, the people it worked for stayed and said so
slightly off topic but is there a reason to titrate slower than the four week schedule
coming back to this 40 units of a 5 solution is a lot of volume and i check that one twice every single time, n of 1 obviously
anyone tracked whether the GI difference held at the top doses
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone