at 15 the GI came back for me, so my easier profile claim only applies below that
#tirzepatide 2026-03-06
Friday30 messages4 participantstimes are UTC
Highlights from this day
- taper_or_not — ok so no gap when i switched, took the last semaglutide dose and started this a week later 5 was where i first noticed it properly, 2.5 did almost nothing for me 07:01
- taper_or_not — switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it 07:19
- taper_or_not — did anyone go past 15 and was there any point to it SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 07:26
- willow_waits — if youre coming off semaglutide the honest answer is start low and find out, theres no table 07:33
- wrong_network — changed my mind about needing 15, i was chasing a number rather than an outcome 08:01
5 did nothing
titrate slow
ok so no gap when i switched, took the last semaglutide dose and started this a week later
5 was where i first noticed it properly, 2.5 did almost nothing for me
no clean conversion
is 7.5 really the sweet spot or is that just channel folklore
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
🔥4👀16👍1
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the 40 vial in 2ml gives 2.5mg/ml which puts 1.7 on 5 units, nice round numbers
did anyone go past 15 and was there any point to it
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
quick one anyone tracked whether the GI difference held at the top doses
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
[edited]if youre coming off semaglutide the honest answer is start low and find out, theres no table
🤝10📈4
easier gi for me
plateaued at 9 weeks the same way i did on semaglutide, so i doubt its compound specific
folklore probably
did anybody switch back to semaglutide after trying this
went back to semaglutide after 25 months because the cost difference mattered more than the GI
how many weeks at 7.5 before you knew it was enough
GIP plus GLP-1
i argued the sweet spot was nonsense and then spent 5 months at 7.5 not needing more
same plateau here
12 did nothing extra over 10 for me and that still holds a year later
changed my mind about needing 15, i was chasing a number rather than an outcome
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)unrelated but the sweet spot argument is really about effect per side effect, not a magic number
[edited]back after 25 months, do i restart at 2.5 or pick up near where i left off
the trials titrated every four weeks to a target, most people here stop at whatever works
the switch felt like a step down at first and then caught up around week 19
*week 29 not week 9