i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
there is no clean conversion between the two, anyone giving you a ratio is guessing
#tirzepatide 2025-09-04
Thursday57 messages11 participantstimes are UTC
Highlights from this day
- reading_the_pins — my Medutest result on a SGN vial came in at 99.4 which is why i keep buying from them 14:20
- verify_or_dont — whats the plateau pattern here, same as semaglutide or different 14:41
- reading_the_pins — no gap when i switched, took the last semaglutide dose and started this a week later 14:46
- question_queue — did anyone go past 15 and was there any point to it 17:22
- verify_or_dont — im at 5 and thinking about 0.5, did anyone gain anything from that step 18:39
start low anyway
my Medutest result on a SGN vial came in at 99.4 which is why i keep buying from them
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GIP plus GLP-1
🎉8🤝14🔥8
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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reading_the_pinsmy Medutest result on a SGN vial came in at 99.4 which is why i keep buying from them
whats the plateau pattern here, same as semaglutide or different
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)went back to semaglutide after 5 months because the cost difference mattered more than the GI
no gap when i switched, took the last semaglutide dose and started this a week later
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the sweet spot argument is really about effect per side effect, not a magic number
restarted at 2.5 after 13 months off and the first two doses reminded me why titration exists
5 was where i first noticed it properly, 2.5 did almost nothing for me
same plateau here
ok so the 2.5 to 5 step was the roughest one for me and everything after was easier
Inter-lab diff for lot B-0114: 99.4% vs 98.6%. Within expected range.
i sat at 7.5 for 25 months and never needed more, which is where the folklore comes from, thats just me
5 did nothing
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
12 did nothing extra over 10 for me and that still holds a year later
changed my mind about needing 15, i was chasing a number rather than an outcome
how many weeks at 7.5 before you knew it was enough
the two compounds arent interchangeable week for week even if the effect ends up similar, ask me again in a month
[edited]does switching from semaglutide need a gap or do you just start
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
*VendorInvestigate not the other one
easier gi for me
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
$240 for a 40 vial is roughly what ive paid for the last year
checked the units twice
Digest for the week of 2025-01-31 has been published.
held 10 for 7 months and lost 10kg over that stretch, slow and boring and fine
does the appetite effect feel different or just stronger
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how did people handle the 2.5 to 5 jump
did anyone go past 15 and was there any point to it
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*PeptideMeter not the other one
at 15 the GI came back for me, so my easier profile claim only applies below that
7.5 gang
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the GI difference held for me right up to 15, which isnt what a couple of people here found, ymmv
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
[edited]folklore probably
titrate slow
plateaued at 23 weeks the same way i did on semaglutide, so i doubt its compound specific
there is no clean conversion between the two, anyone giving you a ratio is guessing
im at 5 and thinking about 0.5, did anyone gain anything from that step
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the sweet spot thing is survivorship, the people it worked for stayed and said so
*VendorInvestigate not the other one
15 is the top
the 20 vial in 0.5ml gives 10mg/ml which puts 1.7 on 30 units, nice round numbers
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
coming off semaglutide, is there a conversion or do i restart at 2.5
switched last year
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
40 units of a 10 solution is a lot of volume and i check that one twice every single time
[edited]SURMOUNT is weight
why does everyone talk about 7.5 and not 10
Batch lookup G-0641: 3 independent reports on file, earliest 2024-10-29.
i log everything and my appetite curve looks flatter across the week than my semaglutide log did