genuine question the 2 vial in 3ml gives 8mg/ml which puts 2 on 40 units, nice round numbers
#tirzepatide 2026-01-13
Tuesday57 messages11 participantstimes are UTC
Highlights from this day
- nordic_price_nils — quick one the switch felt like a step down at first and then caught up around week 8 17:50
- cricket_or_footy — sorry to jump in SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up the 10 vial in 2.5ml gives 10mg/ml which puts 2 on 8 units,… 19:55
- cricket_or_footy — genuine question is 7.5 really the sweet spot or is that just channel folklore 20:32
- sharps_comedy — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 21:25
- sharps_comedy — switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it 22:19
the trials titrated every four weeks to a target, most people here stop at whatever works
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quick one the switch felt like a step down at first and then caught up around week 8
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back after 21 months, do i restart at 2.5 or pick up near where i left off
ok so at 15 the GI came back for me, so my easier profile claim only applies below that
unrelated but how long before the dual thing was noticeable to you
folklore probably
if youre coming off semaglutide the honest answer is start low and find out, theres no table
quick one is SURMOUNT-OSA the sleep apnoea one
10 was enough
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at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
checked the units twice
the sweet spot argument is really about effect per side effect, not a magic number
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
coming back to this restarted at 2.5 after 26 months off and the first two doses reminded me why titration exists
held 10 for 18 months and lost 48kg over that stretch, slow and boring and fine
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
5 did nothing
went back to semaglutide after 25 months because the cost difference mattered more than the GI
GIP plus GLP-1
is the sweet spot argument about effect or about side effects
did anyone find the GI easier than semaglutide at an equivalent effect
£38 for a 20 vial is roughly what ive paid for the last year
same plateau here
changed my mind about needing 15, i was chasing a number rather than an outcome
slightly off topic but i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from
[edited]i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more
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no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me
how many weeks at 7.5 before you knew it was enough
sorry to jump in SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the 10 vial in 2.5ml gives 10mg/ml which puts 2 on 8 units, nice round numbers
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titrate slow
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the GI difference held for me right up to 15, which isnt what a couple of people here found
at 1.7 my appetite is gone entirely, did anyone go down rather than up
no gap when i switched, took the last semaglutide dose and started this a week later
coming off semaglutide, is there a conversion or do i restart at 2.5
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genuine question is 7.5 really the sweet spot or is that just channel folklore
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my VendorInvestigate result on a GL Biochem vial came in at 99 which is why i keep buying from them
coming back to this there is no clean conversion between the two, anyone giving you a ratio is guessing
the two compounds arent interchangeable week for week even if the effect ends up similar
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, n of 1 obviously
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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im at 2 and thinking about 5, did anyone gain anything from that step
7.5 gang
start low anyway
did anyone go past 15 and was there any point to it
the 2.5 to 5 step was the roughest one for me and everything after was easier
switched last year
why does everyone talk about 7.5 and not 10
40 units of a 2 solution is a lot of volume and i check that one twice every single time
slightly off topic but whats the plateau pattern here, same as semaglutide or different
[edited]easier gi for me
switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
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plateaued at 11 weeks the same way i did on semaglutide, so i doubt its compound specific
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SURMOUNT is weight