checked the units twice
🧪15
#tirzepatide 2026-03-27
Friday55 messages13 participantstimes are UTC
Highlights from this day
slightly off topic but went back to semaglutide after 2 months because the cost difference mattered more than the GI
ok so the two compounds arent interchangeable week for week even if the effect ends up similar
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
does the appetite effect feel different or just stronger
7.5 gang
the sweet spot thing is survivorship, the people it worked for stayed and said so
[edited]easier gi for me
did anybody switch back to semaglutide after trying this
held 10 for 15 months and lost 5kg over that stretch, slow and boring and fine
😂8🎉5
did anyone find the GI easier than semaglutide at an equivalent effect
did going from 10 semaglutide to 5 of this feel like a step down for anyone
no gap when i switched, took the last semaglutide dose and started this a week later
does switching from semaglutide need a gap or do you just start
fridge-temps.csv
312 rows · not retained in the public archive
🤝1👍3
is the 40 vial the common one or do people use 30
whats the top licensed dose, 15 or does it go higher
there is no clean conversion between the two, anyone giving you a ratio is guessing
🧊12
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
15 is the top
how did people handle the 2.5 to 5 jump
📉9💀6❤️15
same plateau here
📉10✅18
the switch felt like a step down at first and then caught up around week 7
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
anyone stopped at 10 and stayed there for months
back after 21 months, do i restart at 2.5 or pick up near where i left off
the trials titrated every four weeks to a target, most people here stop at whatever works
did anyone go past 15 and was there any point to it
update on the earlier thing no gap when i switched, took the last semaglutide dose and started this a week later
[edited]coming off semaglutide, is there a conversion or do i restart at 2.5
the trials titrated every four weeks to a target, most people here stop at whatever works
folklore probably
is the sweet spot argument about effect or about side effects
😂8
at 15 the GI came back for me, so my easier profile claim only applies below that, happy to be corrected
whats the plateau pattern here, same as semaglutide or different
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
5 did nothing
is there a reason to titrate slower than the four week schedule
40 units of a 5 solution is a lot of volume and i check that one twice every single time
plateaued at 34 weeks the same way i did on semaglutide, so i doubt its compound specific
anyone got a 2 recon they like for the 40 vials
titrate slow
at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win
how many weeks at 7.5 before you knew it was enough
switched last year
i sat at 7.5 for 14 months and never needed more, which is where the folklore comes from
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
changed my mind about needing 15, i was chasing a number rather than an outcome
for the archive the 2.5 to 5 step was the roughest one for me and everything after was easier
no clean conversion
GIP plus GLP-1
while im here restarted at 2.5 after 1 months off and the first two doses reminded me why titration exists
im at 12 and thinking about 7.5, did anyone gain anything from that step
12 did nothing extra over 10 for me and that still holds a year later