titrate slow
#tirzepatide 2026-06-24
Wednesday47 messages12 participantstimes are UTC
Highlights from this day
- maple_maths — whats the plateau pattern here, same as semaglutide or different 20:59
- half_life_hal — 12 did nothing extra over 10 for me and that still holds a year later 21:02
- taper_or_not — my VendorInvestigate result on a SGN vial came in at 97.4 which is why i keep buying from them 21:47
- tga_notice — 40 units of a 2 solution is a lot of volume and i check that one twice every single time 23:08
- osier_orders — coming off semaglutide, is there a conversion or do i restart at 2.5 23:12
genuine question the sweet spot argument is really about effect per side effect, not a magic number
folklore probably
plateaued at 33 weeks the same way i did on semaglutide, so i doubt its compound specific
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
whats the plateau pattern here, same as semaglutide or different
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is the sweet spot argument about effect or about side effects
[edited]12 did nothing extra over 10 for me and that still holds a year later
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changed my mind about needing 15, i was chasing a number rather than an outcome
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licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, we shall see
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went back to semaglutide after 23 months because the cost difference mattered more than the GI, someone check my working
5 was where i first noticed it properly, 2.5 did almost nothing for me
quick one how did people handle the 2.5 to 5 jump
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i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from
Digest for the week of 2025-08-29 has been published.
switched last year
15 is the top
checked the units twice
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*VendorInvestigate not the other one
my VendorInvestigate result on a SGN vial came in at 97.4 which is why i keep buying from them
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for the archive anyone tracked whether the GI difference held at the top doses
back after 2 months, do i restart at 2.5 or pick up near where i left off
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it, anyway
how long before the dual thing was noticeable to you
10 was enough
how many weeks at 7.5 before you knew it was enough
GIP plus GLP-1
if youre coming off semaglutide the honest answer is start low and find out, theres no table
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
no clean conversion
is 7.5 really the sweet spot or is that just channel folklore
restarted at 2.5 after 25 months off and the first two doses reminded me why titration exists
the GI difference held for me right up to 15, which isnt what a couple of people here found
same plateau here
does the appetite effect feel different or just stronger
5 did nothing
anyone stopped at 10 and stayed there for months
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did anyone find the GI easier than semaglutide at an equivalent effect
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the trials titrated every four weeks to a target, most people here stop at whatever works
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
is the 2 vial the common one or do people use 40
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
40 units of a 2 solution is a lot of volume and i check that one twice every single time
coa-a-2601.pdf
1 page · 182 KB · not retained in the public archive
does switching from semaglutide need a gap or do you just start
coming off semaglutide, is there a conversion or do i restart at 2.5
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the two compounds arent interchangeable week for week even if the effect ends up similar